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Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome

COVID-19 patients can present with pulmonary edema early in disease. We propose that this is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) and B2R on endothelial cells in the lungs. SARS-CoV-2 enters the cell via ACE2 that next to its role in RAAS is needed to...

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Detalles Bibliográficos
Autores principales:	van de Veerdonk, Frank L, Netea, Mihai G, van Deuren, Marcel, van der Meer, Jos WM, de Mast, Quirijn, Brüggemann, Roger J, van der Hoeven, Hans
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Human Biology and Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213974/ https://www.ncbi.nlm.nih.gov/pubmed/32338605 http://dx.doi.org/10.7554/eLife.57555

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