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The dynamic interplay of host and viral enzymes in type III CRISPR-mediated cyclic nucleotide signalling

Cyclic nucleotide second messengers are increasingly implicated in prokaryotic anti-viral defence systems. Type III CRISPR systems synthesise cyclic oligoadenylate (cOA) upon detecting foreign RNA, activating ancillary nucleases that can be toxic to cells, necessitating mechanisms to remove cOA in s...

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Detalles Bibliográficos
Autores principales:	Athukoralage, Januka S, Graham, Shirley, Rouillon, Christophe, Grüschow, Sabine, Czekster, Clarissa M, White, Malcolm F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213978/ https://www.ncbi.nlm.nih.gov/pubmed/32338598 http://dx.doi.org/10.7554/eLife.55852

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