Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism

Notch pathway haploinsufficiency can cause severe developmental syndromes with highly variable penetrance. Currently, we have a limited mechanistic understanding of phenotype variability due to gene dosage. Here, we unexpectedly found that inserting an enhancer containing pioneer transcription facto...

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Detalles Bibliográficos
Autores principales: Kuang, Yi, Golan, Ohad, Preusse, Kristina, Cain, Brittany, Christensen, Collin J, Salomone, Joseph, Campbell, Ian, Okwubido-Williams, FearGod V, Hass, Matthew R, Yuan, Zhenyu, Eafergan, Nathanel, Moberg, Kenneth H, Kovall, Rhett A, Kopan, Raphael, Sprinzak, David, Gebelein, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213981/
https://www.ncbi.nlm.nih.gov/pubmed/32297857
http://dx.doi.org/10.7554/eLife.53659

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