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Polar pattern formation induced by contact following locomotion in a multicellular system

Biophysical mechanisms underlying collective cell migration of eukaryotic cells have been studied extensively in recent years. One mechanism that induces cells to correlate their motions is contact inhibition of locomotion, by which cells migrating away from the contact site. Here, we report that ta...

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Autores principales: Hayakawa, Masayuki, Hiraiwa, Tetsuya, Wada, Yuko, Kuwayama, Hidekazu, Shibata, Tatsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213982/
https://www.ncbi.nlm.nih.gov/pubmed/32352381
http://dx.doi.org/10.7554/eLife.53609
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author Hayakawa, Masayuki
Hiraiwa, Tetsuya
Wada, Yuko
Kuwayama, Hidekazu
Shibata, Tatsuo
author_facet Hayakawa, Masayuki
Hiraiwa, Tetsuya
Wada, Yuko
Kuwayama, Hidekazu
Shibata, Tatsuo
author_sort Hayakawa, Masayuki
collection PubMed
description Biophysical mechanisms underlying collective cell migration of eukaryotic cells have been studied extensively in recent years. One mechanism that induces cells to correlate their motions is contact inhibition of locomotion, by which cells migrating away from the contact site. Here, we report that tail-following behavior at the contact site, termed contact following locomotion (CFL), can induce a non-trivial collective behavior in migrating cells. We show the emergence of a traveling band showing polar order in a mutant Dictyostelium cell that lacks chemotactic activity. We find that CFL is the cell–cell interaction underlying this phenomenon, enabling a theoretical description of how this traveling band forms. We further show that the polar order phase consists of subpopulations that exhibit characteristic transversal motions with respect to the direction of band propagation. These findings describe a novel mechanism of collective cell migration involving cell–cell interactions capable of inducing traveling band with polar order.
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spelling pubmed-72139822020-05-13 Polar pattern formation induced by contact following locomotion in a multicellular system Hayakawa, Masayuki Hiraiwa, Tetsuya Wada, Yuko Kuwayama, Hidekazu Shibata, Tatsuo eLife Physics of Living Systems Biophysical mechanisms underlying collective cell migration of eukaryotic cells have been studied extensively in recent years. One mechanism that induces cells to correlate their motions is contact inhibition of locomotion, by which cells migrating away from the contact site. Here, we report that tail-following behavior at the contact site, termed contact following locomotion (CFL), can induce a non-trivial collective behavior in migrating cells. We show the emergence of a traveling band showing polar order in a mutant Dictyostelium cell that lacks chemotactic activity. We find that CFL is the cell–cell interaction underlying this phenomenon, enabling a theoretical description of how this traveling band forms. We further show that the polar order phase consists of subpopulations that exhibit characteristic transversal motions with respect to the direction of band propagation. These findings describe a novel mechanism of collective cell migration involving cell–cell interactions capable of inducing traveling band with polar order. eLife Sciences Publications, Ltd 2020-04-30 /pmc/articles/PMC7213982/ /pubmed/32352381 http://dx.doi.org/10.7554/eLife.53609 Text en © 2020, Hayakawa et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Physics of Living Systems
Hayakawa, Masayuki
Hiraiwa, Tetsuya
Wada, Yuko
Kuwayama, Hidekazu
Shibata, Tatsuo
Polar pattern formation induced by contact following locomotion in a multicellular system
title Polar pattern formation induced by contact following locomotion in a multicellular system
title_full Polar pattern formation induced by contact following locomotion in a multicellular system
title_fullStr Polar pattern formation induced by contact following locomotion in a multicellular system
title_full_unstemmed Polar pattern formation induced by contact following locomotion in a multicellular system
title_short Polar pattern formation induced by contact following locomotion in a multicellular system
title_sort polar pattern formation induced by contact following locomotion in a multicellular system
topic Physics of Living Systems
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213982/
https://www.ncbi.nlm.nih.gov/pubmed/32352381
http://dx.doi.org/10.7554/eLife.53609
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