Cargando…

ML264 inhibits osteosarcoma growth and metastasis via inhibition of JAK2/STAT3 and WNT/β‐catenin signalling pathways

Osteosarcoma, the most common bone malignancy, has a high morbidity rate and poor prognosis. Krüppel‐like factor 5 (KLF5) is a key transcriptional regulator of cellular proliferation whose overexpression is observed in osteosarcoma cell lines (U2OS, 143B, MG63 and SAOS2). ML264, a small‐molecule inh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Hai, Han, Ying, Chen, Zhijun, Pan, Xin, Yuan, Putao, Zhao, Xiangde, Zhu, Hongfang, Wang, Jiying, Sun, Xuewu, Shi, Peihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214147/ https://www.ncbi.nlm.nih.gov/pubmed/32285603 http://dx.doi.org/10.1111/jcmm.15226

Ejemplares similares

USP1 inhibition suppresses the progression of osteosarcoma via destabilizing TAZ
por: Yuan, Putao, et al.
Publicado: (2022)

Tanshinone I inhibits the growth and metastasis of osteosarcoma via suppressing JAK/STAT3 signalling pathway
por: Wang, Weiguo, et al.
Publicado: (2019)

COL5A2 Inhibits the TGF-β and Wnt/β-Catenin Signaling Pathways to Inhibit the Invasion and Metastasis of Osteosarcoma
por: Han, Yan-Long, et al.
Publicado: (2022)

The Nrf2 activator RTA-408 attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling
por: Sun, Xuewu, et al.
Publicado: (2019)

FANCD2 inhibits ferroptosis by regulating the JAK2/STAT3 pathway in osteosarcoma
por: Li, Xujun, et al.
Publicado: (2023)

DUSP6 expression is associated with osteoporosis through the regulation of osteoclast differentiation via ERK2/Smad2 signaling
por: Zhang, Boya, et al.
Publicado: (2021)

Ginsenoside Rg3 Inhibits the Growth of Osteosarcoma and Attenuates Metastasis through the Wnt/β-Catenin and EMT Signaling Pathway
por: Mao, Xiaohan, et al.
Publicado: (2020)

Resveratrol Loaded by Folate-Modified Liposomes Inhibits Osteosarcoma Growth and Lung Metastasis via Regulating JAK2/STAT3 Pathway
por: Zhu, Wen Ting, et al.
Publicado: (2023)

FOXO1 inhibits osteosarcoma oncogenesis via Wnt/β-catenin pathway suppression
por: Guan, H, et al.
Publicado: (2015)

Dihydrotanshinone I inhibits the growth of osteosarcoma through the Wnt/β-catenin signaling pathway
por: Tan, Tao, et al.
Publicado: (2019)

Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways
por: Yang, Chunmei, et al.
Publicado: (2020)

An overview of JAK/STAT pathways and JAK inhibition in alopecia areata
por: Lensing, Maddison, et al.
Publicado: (2022)

Liensinine Inhibits Osteosarcoma Growth by ROS-Mediated Suppression of the JAK2/STAT3 Signaling Pathway
por: Jia, Fei, et al.
Publicado: (2022)

Baicalein inhibits progression of osteosarcoma cells through inactivation of the Wnt/β-catenin signaling pathway
por: Dai, Guo, et al.
Publicado: (2017)

Caudatin Inhibits the Proliferation, Invasion, and Glycolysis of Osteosarcoma Cells via the Wnt/β- Catenin Pathway
por: Zhang, Yan, et al.
Publicado: (2022)

Dihydrotanshinone I Inhibits the Growth of Osteosarcoma Through the Wnt/β-Catenin Signaling Pathway [Retraction]
Publicado: (2023)

Inhibition of STAT3 blocks protein synthesis and tumor metastasis in osteosarcoma cells
por: Zuo, Dongqing, et al.
Publicado: (2018)

PARK2 inhibits osteosarcoma cell growth through the JAK2/STAT3/VEGF signaling pathway
por: Lei, Zhong, et al.
Publicado: (2018)

Schisandrin B suppresses osteosarcoma lung metastasis in vivo by inhibiting the activation of the Wnt/β-catenin and PI3K/Akt signaling pathways
por: Wang, Yuping, et al.
Publicado: (2022)

Epigallocatechin-3-gallate suppresses the growth of human osteosarcoma by inhibiting the Wnt/β-catenin signalling pathway
por: Dong, Chaoqun, et al.
Publicado: (2022)

Isoquercitrin restrains the proliferation and promotes apoptosis of human osteosarcoma cells by inhibiting the Wnt/β-catenin pathway
por: Wei, Zhun, et al.
Publicado: (2023)

A review of JAK–STAT signalling in the pathogenesis of spondyloarthritis and the role of JAK inhibition
por: McInnes, Iain B, et al.
Publicado: (2021)

Aloin suppresses lipopolysaccharide-induced inflammation by inhibiting JAK1-STAT1/3 activation and ROS production in RAW264.7 cells
por: Ma, Yunfei, et al.
Publicado: (2018)

Fraxetin Inhibits the Proliferation and Metastasis of Glioma Cells by Inactivating JAK2/STAT3 Signaling
por: Qu, Liangchen, et al.
Publicado: (2021)

The molecular basis of JAK/STAT inhibition by SOCS1
por: Liau, Nicholas P. D., et al.
Publicado: (2018)

ZNF671 Inhibits the Proliferation and Metastasis of NSCLC via the Wnt/β-Catenin Pathway
por: Zhan, Wei, et al.
Publicado: (2020)

Inhibition of oleandrin on the proliferation show and invasion of osteosarcoma cells in vitro by suppressing Wnt/β-catenin signaling pathway
por: Ma, Yunlong, et al.
Publicado: (2015)

LncRNA BE503655 inhibits osteosarcoma cell proliferation, invasion/migration via Wnt/β-catenin pathway
por: Huang, Qiang, et al.
Publicado: (2019)

Cinnamaldehyde Inhibits the Function of Osteosarcoma by Suppressing the Wnt/β-Catenin and PI3K/Akt Signaling Pathways
por: Huang, Yanran, et al.
Publicado: (2020)

Silencing of RIPK4 inhibits epithelial-mesenchymal transition by inactivating the Wnt/β-catenin signaling pathway in osteosarcoma
por: Yi, Zhigang, et al.
Publicado: (2020)

Down-regulation of PRR11 affects the proliferation, migration and invasion of osteosarcoma by inhibiting the Wnt/β-catenin pathway
por: Li, Ke, et al.
Publicado: (2021)

Silencing of RIPK4 inhibits epithelial-mesenchymal transition by inactivating the Wnt/β-catenin signaling pathway in osteosarcoma
por: Yi, Zhigang, et al.
Publicado: (2022)

Overexpression of cytoplasmic β-catenin inhibits the metastasis of the murine osteosarcoma cell line LM8
por: Kidani, Teruki, et al.
Publicado: (2014)

Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway
por: Ma, Xingcong, et al.
Publicado: (2016)

Sevoflurane Inhibited Osteosarcoma Cell Proliferation And Invasion Via Targeting miR-203/WNT2B/Wnt/β-Catenin Axis
por: Chen, Meixian, et al.
Publicado: (2019)

Triptonide Effectively Inhibits Wnt/β-Catenin Signaling via C-terminal Transactivation Domain of β-catenin
por: Chinison, Jessica, et al.
Publicado: (2016)

Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition
por: Zhang, Tao, et al.
Publicado: (2016)

Pharmacologic inhibition of JAK-STAT signaling promotes hair growth
por: Harel, Sivan, et al.
Publicado: (2015)

Pharmacological inhibition of demethylzeylasteral on JAK-STAT signaling ameliorates vitiligo
por: Chang, Yuqian, et al.
Publicado: (2023)

NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway
por: Li, Jingrong, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_80n1krmsfes4leo43gfh1c32km