Cargando…

Utilization of Physiologically Based Pharmacokinetic Modeling in Clinical Pharmacology and Therapeutics: an Overview

The purpose of this review was to assess the advancement of applications for physiologically based pharmacokinetic (PBPK) modeling in various therapeutic areas. We conducted a PubMed search, and 166 articles published between 2012 and 2018 on FDA-approved drug products were selected for further revi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Perry, Courtney, Davis, Grace, Conner, Todd M., Zhang, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2020
Materias:	Precision Medicine and Pharmacogenomics (S Nair, Section Editor)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214223/ https://www.ncbi.nlm.nih.gov/pubmed/32399388 http://dx.doi.org/10.1007/s40495-020-00212-x

Ejemplares similares

Impact of cytochrome P450 2C19 polymorphisms on the pharmacokinetics of tacrolimus when coadministered with voriconazole
por: Imamura, Chiyo K., et al.
Publicado: (2015)

Effect of uptake transporters OAT3 and OATP1B1 and efflux transporter MRP2 on the pharmacokinetics of eluxadoline
por: Davenport, J Michael, et al.
Publicado: (2015)

Meta‐Analysis of Noncompartmental Pharmacokinetic Parameters of Ertugliflozin to Evaluate Dose Proportionality and UGT1A9 Polymorphism Effect on Exposure
por: Marshall, Jean‐Claude, et al.
Publicado: (2021)

No Clinical Impact of CYP3A5 Gene Polymorphisms on the Pharmacokinetics and/or Efficacy of Maraviroc in Healthy Volunteers and HIV‐1–Infected Subjects
por: Vourvahis, Manoli, et al.
Publicado: (2018)

CYP2B6*6 Genotype Specific Differences in Artemether‐Lumefantrine Disposition in Healthy Volunteers
por: Abdullahi, Sa'ad T., et al.
Publicado: (2019)

Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations
por: Scotcher, Daniel, et al.
Publicado: (2017)

81030 Utilizing a synergistic drug combination to target relapsed/refractory FLT3 mutant AML
por: Jones, LaQuita, et al.
Publicado: (2021)

4061 Clinical utility of precision medicine approaches to guide anti-platelet selection for adult patients with acute coronary syndromes (ACS), following percutaneous coronary intervention (PCI)
por: Mosley, Scott, et al.
Publicado: (2020)

Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System
por: Tsamandouras, N., et al.
Publicado: (2017)

Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice
por: McMillan, JoEllyn M., et al.
Publicado: (2018)

Regulation of UGT2A1 by miR-196a-5p and miR-196b-5p
por: Sutliff, Aimee K., et al.
Publicado: (2019)

278 Eight Pharmacokinetic-related Genetic Variants Were Not Associated with Bleeding from Direct Oral Anticoagulants in Non-valvular Atrial Fibrillation Patients
por: Campos-Staffico, Alessandra M., et al.
Publicado: (2023)

4429 Powering precision medicine research with the efficient construction of large diverse cohorts
por: Petukhova, Lynn, et al.
Publicado: (2020)

4058 Enhanced efficiency of large-scale clinical proteomic studies: when less is more
por: Thomas, Stefani, et al.
Publicado: (2020)

4199 A pilot randomized controlled trial of precision care for smoking cessation in the Southern Community Cohort Study
por: Senft, Nicole, et al.
Publicado: (2020)

4513 European Ancestry as a Risk Factor for Atrial Fibrillation in Puerto Rican Hispanics
por: Gonzalez-Cordero, Ariel
Publicado: (2020)

4440 Enhanced radiation therapy using chlorin-e6 conjugated gold nanoparticles
por: Jenkins, Samir V, et al.
Publicado: (2020)

4089 Clinical Implementation of Monte Carlo Dose Calculation for Patient-Specific Radiotherapy Quality Assurance
por: Parenica, Holly Marie, et al.
Publicado: (2020)

4228 A latent class analysis of seriously ill adults with multiple chronic conditions receiving palliative care
por: Murali, Komal, et al.
Publicado: (2020)

4292 Epigenetic Age and Depressive Symptoms in African American Women with Cardiometabolic Conditions
por: Perez, Nicole B, et al.
Publicado: (2020)

4167 Peri-transplant Lung Microbiome Reveal Oral Bacteria, Pepsin And Inflammatory Markers Co-associate With Primary Graft Dysfunction, Implicating Aspiration As A Potential Contributor
por: McGinniss, John Evan, et al.
Publicado: (2020)

4043 Saliva microRNA for pediatric concussion assessment
por: Hicks, Steven, et al.
Publicado: (2020)

4565 Sex-Specific Differences in the Genomic Landscape of Pediatric and Adult Glioblastoma
por: Ivanov, Nikolay A., et al.
Publicado: (2020)

4106 Personalizing Care For Colorectal Cancer: Identifying Novel Opportunities
por: Rivers, Zachary, et al.
Publicado: (2020)

4482 Horizontal ridge augmentation in maxilla using bone expansion vs bone splitting techniques in adult patients: a prospective cohort
por: Acevedo, Amanda Figueroa, et al.
Publicado: (2020)

4518 Metabolomic Identifiers Predictive of Adverse Events due to Acetaminophen Administration
por: Sonn, Brandon Joseph, et al.
Publicado: (2020)

4360 Black Bone MRI from the Lab to Clinical Practice: Eliminating Radiation Exposure in Reconstructive Surgery Patients
por: Suchyta, Marissa, et al.
Publicado: (2020)

4023 Catecholamines and Opioid Therapy Requirements for the Management of Acute Post-Procedural Pain: The clinical Trend to Identify Remarkable Elements in Opioid Drug Dependency
por: Rivera, Armando Uribe, et al.
Publicado: (2020)

4385 The Pain and Social Experiences Project: Understanding the role of interpersonal trauma in pain
por: Pierce, Jennifer, et al.
Publicado: (2020)

4267 Noninvasive hybrid ultrasound and photoacoustic imaging for the assessment of liver fibrosis
por: Sultan, Laith Riyadh, et al.
Publicado: (2020)

4146 Establishment of Screening Methods for G6DP Deficiency – Translational and Clinical Applications
por: Gomez, Christian, et al.
Publicado: (2020)

4260 Hollow, Degradable poly(N-Isopropylacrylamide) Derived Nanoparticles for the Delivery of Anti-Inflammatory Peptides for the Treatment and Prevention of Post-Traumatic Osteoarthritis
por: Deloney, Marcus A, et al.
Publicado: (2020)

4168 Understanding ECM-Based Drug Resistivity in Breast Cancer
por: Libring, Sarah, et al.
Publicado: (2020)

4108 Artificial Intelligence-Based Quantification of the General Movement Assessment Using Center of Pressure Patterns in Healthy Infants
por: Johnson, Tara Lynn, et al.
Publicado: (2020)

4485 Silicone Implant Shells Increase the Rate of Proliferation of Patient-Derived BIA-ALCL Cells but Not Primary T Cells in an Engineered Biomimetic Breast Platform
por: Premaratne, Ishani, et al.
Publicado: (2020)

4423 Impact of Gender on High On-Treatment Platelet Reactivity (HPR) and Major Adverse Cardiovascular Events (MACEs) in Caribbean Hispanic patients using Clopidogrel
por: Nunez Medina, Hector Jose, et al.
Publicado: (2020)

54443 Pharmacogenomic Profiling of East and West African Populations
por: Jackson, Linsey, et al.
Publicado: (2021)

82786 Quantification of the Accuracy of Stereotactic Radiosurgery using Surface Guided Imaging with 3D Printed Head Phantoms
por: Bry, Victoria, et al.
Publicado: (2021)

48352 Mechanisms Underlying Lipidomic Changes in Major Depressive Disorder
por: Costa, Ana Paula, et al.
Publicado: (2021)

17230 Agreement between point-of-care intestinal ultrasound (POCUS) and magnetic resonance enterography for assessment of the terminal ileum through sigmoid colon in pediatric patients with inflammatory bowel diseases: A diagnostic cross-sectional study
por: Chavannes, Mallory, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_g6qdhajat3cqlfk6r8fga7pa0i