Elevated Hedgehog activity contributes to attenuated DNA damage responses in aged hematopoietic cells

Accumulation of DNA damage and myeloid-skewed differentiation characterize aging of the hematopoietic system, yet underlying mechanisms remain incompletely understood. Here, we show that aging hematopoietic progenitor cells particularly of the myeloid branch exhibit enhanced resistance to bulky DNA...

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Detalles Bibliográficos
Autores principales: Scheffold, Annika, Baig, Ali H., Chen, Zhiyang, von Löhneysen, Sarah E., Becker, Friedrich, Morita, Yohei, Avila, Alush I., Groth, Marco, Lechel, André, Schmid, Florian, Kraus, Johann M., Kestler, Hans A., Stilgenbauer, Stephan, Philipp, Melanie, Burkhalter, Martin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214262/
https://www.ncbi.nlm.nih.gov/pubmed/31728056
http://dx.doi.org/10.1038/s41375-019-0641-3

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