Cargando…

Physiological levels of the PTEN-PI3K-AKT axis activity are required for maintenance of Burkitt lymphoma

In addition to oncogenic MYC translocations, Burkitt lymphoma (BL) depends on the germinal centre (GC) dark zone (DZ) B cell survival and proliferation programme, which is characterized by relatively low PI3K-AKT activity. Paradoxically, PI3K-AKT activation facilitates MYC-driven lymphomagenesis in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gehringer, Franziska, Weissinger, Stephanie Ellen, Möller, Peter, Wirth, Thomas, Ushmorov, Alexey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214272/ https://www.ncbi.nlm.nih.gov/pubmed/31719683 http://dx.doi.org/10.1038/s41375-019-0628-0

Ejemplares similares

FOXO1 Confers Maintenance of the Dark Zone Proliferation and Survival Program and Can Be Pharmacologically Targeted in Burkitt Lymphoma
por: Gehringer, Franziska, et al.
Publicado: (2019)

Role and mechanism of PTEN in Burkitt's lymphoma
por: Li, Chuntuan, et al.
Publicado: (2020)

SPAG6 promotes cell proliferation and inhibits apoptosis through the PTEN/PI3K/AKT pathway in Burkitt lymphoma
por: Zhang, Rongrong, et al.
Publicado: (2020)

FOXO1 downregulation contributes to the oncogenic program of primary mediastinal B-cell lymphoma
por: Xie, Linka, et al.
Publicado: (2014)

Tuberous sclerosis complex is required for tumor maintenance in MYC‐driven Burkitt's lymphoma
por: Hartleben, Götz, et al.
Publicado: (2018)

Pre-clinical activity of targeting the PI3K/Akt/mTOR pathway in Burkitt lymphoma
por: Bhatti, Maria, et al.
Publicado: (2018)

CCND3 is indispensable for the maintenance of B-cell acute lymphoblastic leukemia
por: Ketzer, Franz, et al.
Publicado: (2022)

The PTEN–PI3K Axis in Cancer
por: Papa, Antonella, et al.
Publicado: (2019)

Burkitt Lymphoma in the Mouse
por: Kovalchuk, Alexander L., et al.
Publicado: (2000)

Burkitt Lymphoma of the Duodenum
por: Matsueda, Katsunori, et al.
Publicado: (2017)

Burkitt's lymphoma of the mandible
por: Kuo, Ying-Shiung, et al.
Publicado: (2017)

Down-regulation of the PI3K/Akt signaling pathway and induction of apoptosis in CA46 Burkitt lymphoma cells by baicalin
por: Huang, Yi, et al.
Publicado: (2012)

MEK1 Is Required for PTEN Membrane Recruitment, AKT Regulation, and the Maintenance of Peripheral Tolerance
por: Zmajkovicova, Katarina, et al.
Publicado: (2013)

Excretion of Immunoglobulins in Burkitt's Lymphoma
por: McFarlane, H., et al.
Publicado: (1970)

Pleural effusion in Burkitt's lymphoma.
por: Aderele, W. I., et al.
Publicado: (1975)

Cytology and Histochemistry of the Burkitt Lymphoma
por: Wright, D. H.
Publicado: (1963)

The next step for Burkitt lymphoma
por: Cho, Bin
Publicado: (2011)

Denis Burkitt and the African lymphoma
por: Magrath, I
Publicado: (2009)

Burkitts’s lymphoma – an atypical presentation
por: Ziade, Farah, et al.
Publicado: (2012)

Seasonality of Burkitt's lymphoma in Uganda
por: Muwazi, L, et al.
Publicado: (2014)

Primary Gastric Burkitt’s Lymphoma
por: Mitra, Swarupa, et al.
Publicado: (2014)

Burkitt Lymphoma: beyond discoveries
por: Mbulaiteye, Sam M
Publicado: (2013)

Primary Gastric Burkitt’s lymphoma:
por: khan, Adnan, et al.
Publicado: (2017)

The burden of Burkitt lymphoma in Africa
por: Hämmerl, Lucia, et al.
Publicado: (2019)

Educational Case: Burkitt Lymphoma
por: Alexander, Caitlin J., et al.
Publicado: (2019)

PTENP1/miR-20a/PTEN axis contributes to breast cancer progression by regulating PTEN via PI3K/AKT pathway
por: Gao, Xue, et al.
Publicado: (2019)

Burkitt Lymphoma as Fourth Neoplasia in a Patient Affected by Cowden Syndrome with a Novel PTEN Germline Pathogenic Variant
por: Galli, Eugenio, et al.
Publicado: (2020)

Burkitt-like lymphoma with 11q aberration: a germinal center-derived lymphoma genetically unrelated to Burkitt lymphoma
por: Gonzalez-Farre, Blanca, et al.
Publicado: (2019)

Targeting the intratumor heterogeneity in PMBL
por: Ritz, Olga, et al.
Publicado: (2014)

Outcomes of Burkitt lymphoma with bone marrow involvement or Burkitt leukemia in Chinese children
por: Zhu, Jia, et al.
Publicado: (2021)

Artesunate, as an Hsp90 inhibitor, inhibits the proliferation of Burkitt’s lymphoma cells by inhibiting AKT and ERK
por: Yuan-Ce, Li, et al.
Publicado: (2023)

Correction: PTENP1/miR-20a/PTEN axis contributes to breast cancer progression by regulating PTEN via PI3K/AKT pathway
por: Gao, Xue, et al.
Publicado: (2023)

Shikonin exerts antitumor activity in Burkitt’s lymphoma by inhibiting C-MYC and PI3K/AKT/mTOR pathway and acts synergistically with doxorubicin
por: Ni, Fan, et al.
Publicado: (2018)

Repression of TCF3/E2A contributes to Hodgkin lymphomagenesis
por: Guan, Hanfeng, et al.
Publicado: (2016)

‘Blastoid’ variant of Burkitt lymphoma with additional partial 1q tetrasomy
por: Siddiqi, Ahsan, et al.
Publicado: (2018)

Burkitt lymphoma in Papua, New Guinea.
por: Booth, K., et al.
Publicado: (1967)

Survival of Burkitt's Lymphoma Patients in Ghana
por: Wosornu, J. L., et al.
Publicado: (1971)

Burkitt's Lymphoma in Ilesha, Western Nigeria
por: Mulligan, T. O.
Publicado: (1971)

Abdominal Burkitt-type lymphomas in Algeria.
por: Ladjadj, Y., et al.
Publicado: (1984)

Burkitt lymphoma masquerading as cardiac tamponade
por: Kaul, Pankaj, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_66qusrfagfum34rn3jdlc42m7u