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Physiological levels of the PTEN-PI3K-AKT axis activity are required for maintenance of Burkitt lymphoma

In addition to oncogenic MYC translocations, Burkitt lymphoma (BL) depends on the germinal centre (GC) dark zone (DZ) B cell survival and proliferation programme, which is characterized by relatively low PI3K-AKT activity. Paradoxically, PI3K-AKT activation facilitates MYC-driven lymphomagenesis in...

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Detalles Bibliográficos
Autores principales:	Gehringer, Franziska, Weissinger, Stephanie Ellen, Möller, Peter, Wirth, Thomas, Ushmorov, Alexey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214272/ https://www.ncbi.nlm.nih.gov/pubmed/31719683 http://dx.doi.org/10.1038/s41375-019-0628-0

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