Loss of KDM6A confers drug resistance in acute myeloid leukemia

Acute myeloid leukemia (AML) is an aggressive hematologic neoplasm resulting from the malignant transformation of myeloid progenitors. Despite intensive chemotherapy leading to initial treatment responses, relapse caused by intrinsic or acquired drug resistance represents a major challenge. Here, we...

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Detalles Bibliográficos
Autores principales: Stief, Sophie M., Hanneforth, Anna-Li, Weser, Sabrina, Mattes, Raphael, Carlet, Michela, Liu, Wen-Hsin, Bartoschek, Michael D., Domínguez Moreno, Helena, Oettle, Matthias, Kempf, Julia, Vick, Binje, Ksienzyk, Bianka, Tizazu, Belay, Rothenberg-Thurley, Maja, Quentmeier, Hilmar, Hiddemann, Wolfgang, Vosberg, Sebastian, Greif, Philipp A., Metzeler, Klaus H., Schotta, Gunnar, Bultmann, Sebastian, Jeremias, Irmela, Leonhardt, Heinrich, Spiekermann, Karsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214274/
https://www.ncbi.nlm.nih.gov/pubmed/31201358
http://dx.doi.org/10.1038/s41375-019-0497-6

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