Ceftolozane/Tazobactam for Treating Children With Exacerbations of Cystic Fibrosis Due to Pseudomonas aeruginosa: A Review of Available Data

Ceftolozane-tazobactam is a novel fifth-generation cephalosporin/β-lactamase inhibitor combination recently approved for treatment of both complicated intra-abdominal and urinary tract infections in adults. Considering its potent bactericidal activity against Pseudomonas aeruginosa, it might represe...

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Autores principales: Garazzino, Silvia, Altieri, Elena, Silvestro, Erika, Pruccoli, Giulia, Scolfaro, Carlo, Bignamini, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214539/
https://www.ncbi.nlm.nih.gov/pubmed/32432060
http://dx.doi.org/10.3389/fped.2020.00173
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author Garazzino, Silvia
Altieri, Elena
Silvestro, Erika
Pruccoli, Giulia
Scolfaro, Carlo
Bignamini, Elisabetta
author_facet Garazzino, Silvia
Altieri, Elena
Silvestro, Erika
Pruccoli, Giulia
Scolfaro, Carlo
Bignamini, Elisabetta
author_sort Garazzino, Silvia
collection PubMed
description Ceftolozane-tazobactam is a novel fifth-generation cephalosporin/β-lactamase inhibitor combination recently approved for treatment of both complicated intra-abdominal and urinary tract infections in adults. Considering its potent bactericidal activity against Pseudomonas aeruginosa, it might represent an important option also for treating children with exacerbations of cystic fibrosis due to Pseudomonas aeruginosa when other alternative treatments have been exhausted. We hereby review available data on the use of ceftolozane-tazobactam in children, focusing on cystic fibrosis.
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spelling pubmed-72145392020-05-19 Ceftolozane/Tazobactam for Treating Children With Exacerbations of Cystic Fibrosis Due to Pseudomonas aeruginosa: A Review of Available Data Garazzino, Silvia Altieri, Elena Silvestro, Erika Pruccoli, Giulia Scolfaro, Carlo Bignamini, Elisabetta Front Pediatr Pediatrics Ceftolozane-tazobactam is a novel fifth-generation cephalosporin/β-lactamase inhibitor combination recently approved for treatment of both complicated intra-abdominal and urinary tract infections in adults. Considering its potent bactericidal activity against Pseudomonas aeruginosa, it might represent an important option also for treating children with exacerbations of cystic fibrosis due to Pseudomonas aeruginosa when other alternative treatments have been exhausted. We hereby review available data on the use of ceftolozane-tazobactam in children, focusing on cystic fibrosis. Frontiers Media S.A. 2020-05-05 /pmc/articles/PMC7214539/ /pubmed/32432060 http://dx.doi.org/10.3389/fped.2020.00173 Text en Copyright © 2020 Garazzino, Altieri, Silvestro, Pruccoli, Scolfaro and Bignamini. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Garazzino, Silvia
Altieri, Elena
Silvestro, Erika
Pruccoli, Giulia
Scolfaro, Carlo
Bignamini, Elisabetta
Ceftolozane/Tazobactam for Treating Children With Exacerbations of Cystic Fibrosis Due to Pseudomonas aeruginosa: A Review of Available Data
title Ceftolozane/Tazobactam for Treating Children With Exacerbations of Cystic Fibrosis Due to Pseudomonas aeruginosa: A Review of Available Data
title_full Ceftolozane/Tazobactam for Treating Children With Exacerbations of Cystic Fibrosis Due to Pseudomonas aeruginosa: A Review of Available Data
title_fullStr Ceftolozane/Tazobactam for Treating Children With Exacerbations of Cystic Fibrosis Due to Pseudomonas aeruginosa: A Review of Available Data
title_full_unstemmed Ceftolozane/Tazobactam for Treating Children With Exacerbations of Cystic Fibrosis Due to Pseudomonas aeruginosa: A Review of Available Data
title_short Ceftolozane/Tazobactam for Treating Children With Exacerbations of Cystic Fibrosis Due to Pseudomonas aeruginosa: A Review of Available Data
title_sort ceftolozane/tazobactam for treating children with exacerbations of cystic fibrosis due to pseudomonas aeruginosa: a review of available data
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214539/
https://www.ncbi.nlm.nih.gov/pubmed/32432060
http://dx.doi.org/10.3389/fped.2020.00173
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