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Endothelial cells derived from patients' induced pluripotent stem cells for sustained factor VIII delivery and the treatment of hemophilia A

Hemophilia A (HA) is a bleeding disorder characterized by spontaneous and prolonged hemorrhage. The disease is caused by mutations in the coagulation factor 8 gene (F8) leading to factor VIII (FVIII) deficiency. Since FVIII is primarily produced in endothelial cells (ECs) in a non‐diseased human bei...

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Detalles Bibliográficos
Autores principales:	Rose, Melanie, Gao, Kewa, Cortez‐Toledo, Elizabeth, Agu, Emmanuel, Hyllen, Alicia A., Conroy, Kelsey, Pan, Guangjin, Nolta, Jan A., Wang, Aijun, Zhou, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2020
Materias:	Pluripotent Stem Cells
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214661/ https://www.ncbi.nlm.nih.gov/pubmed/32162786 http://dx.doi.org/10.1002/sctm.19-0261

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