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Production of Autoreactive Heavy Chain-Only Antibodies in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is characterized by the overproduction of high-affinity autoreactive antibodies. Here, we show that more than 65.8% of 222 recombinant antibodies derived from 8 SLE patients can be secreted as heavy chain-only antibodies (HCAbs) when expressed in HEK-293T cells. Th...

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Detalles Bibliográficos
Autores principales:	Xu, Shu, Yang, Hong, Zhuo, Yue, Yu, Yangsheng, Liao, Hongyan, Li, Song, Yue, Yinshi, Su, Kaihong, Zhang, Zhixin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214812/ https://www.ncbi.nlm.nih.gov/pubmed/32431693 http://dx.doi.org/10.3389/fimmu.2020.00632

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