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Replication Fork Remodeling and Therapy Escape in DNA Damage Response-Deficient Cancers

Most cancers have lost a critical DNA damage response (DDR) pathway during tumor evolution. These alterations provide a useful explanation for the initial sensitivity of tumors to DNA-targeting chemotherapy. A striking example is dysfunctional homology-directed repair (HDR), e.g., due to inactivatin...

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Detalles Bibliográficos
Autores principales:	Liptay, Martin, Barbosa, Joana S., Rottenberg, Sven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214843/ https://www.ncbi.nlm.nih.gov/pubmed/32432041 http://dx.doi.org/10.3389/fonc.2020.00670

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