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Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations
For investigations on the biological functions of oligosaccharides and peptidomimetics, new asparagine-based mono- and disaccharides containing glycopeptides were prepared in solution. The applicability of two common peptide coupling reagents, using an orthogonal Fmoc/t-Bu strategy along with acetyl...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Beilstein-Institut
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214877/ https://www.ncbi.nlm.nih.gov/pubmed/32461770 http://dx.doi.org/10.3762/bjoc.16.80 |
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author | Sršan, Laura Ziegler, Thomas |
author_facet | Sršan, Laura Ziegler, Thomas |
author_sort | Sršan, Laura |
collection | PubMed |
description | For investigations on the biological functions of oligosaccharides and peptidomimetics, new asparagine-based mono- and disaccharides containing glycopeptides were prepared in solution. The applicability of two common peptide coupling reagents, using an orthogonal Fmoc/t-Bu strategy along with acetyl protecting groups for the carbohydrate moiety, was studied. Thus, the prepared libraries of glycopeptides were designed as model systems of cell surfaces for future investigations by combined preparative mass spectroscopy and scanning tunneling microscopy (STM) using soft-landing electrospray beam deposition (ES-IBD), on metal surfaces. |
format | Online Article Text |
id | pubmed-7214877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-72148772020-05-26 Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations Sršan, Laura Ziegler, Thomas Beilstein J Org Chem Full Research Paper For investigations on the biological functions of oligosaccharides and peptidomimetics, new asparagine-based mono- and disaccharides containing glycopeptides were prepared in solution. The applicability of two common peptide coupling reagents, using an orthogonal Fmoc/t-Bu strategy along with acetyl protecting groups for the carbohydrate moiety, was studied. Thus, the prepared libraries of glycopeptides were designed as model systems of cell surfaces for future investigations by combined preparative mass spectroscopy and scanning tunneling microscopy (STM) using soft-landing electrospray beam deposition (ES-IBD), on metal surfaces. Beilstein-Institut 2020-04-30 /pmc/articles/PMC7214877/ /pubmed/32461770 http://dx.doi.org/10.3762/bjoc.16.80 Text en Copyright © 2020, Sršan and Ziegler https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
spellingShingle | Full Research Paper Sršan, Laura Ziegler, Thomas Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations |
title | Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations |
title_full | Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations |
title_fullStr | Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations |
title_full_unstemmed | Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations |
title_short | Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations |
title_sort | synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations |
topic | Full Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214877/ https://www.ncbi.nlm.nih.gov/pubmed/32461770 http://dx.doi.org/10.3762/bjoc.16.80 |
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