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Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations

For investigations on the biological functions of oligosaccharides and peptidomimetics, new asparagine-based mono- and disaccharides containing glycopeptides were prepared in solution. The applicability of two common peptide coupling reagents, using an orthogonal Fmoc/t-Bu strategy along with acetyl...

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Detalles Bibliográficos
Autores principales: Sršan, Laura, Ziegler, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214877/
https://www.ncbi.nlm.nih.gov/pubmed/32461770
http://dx.doi.org/10.3762/bjoc.16.80
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author Sršan, Laura
Ziegler, Thomas
author_facet Sršan, Laura
Ziegler, Thomas
author_sort Sršan, Laura
collection PubMed
description For investigations on the biological functions of oligosaccharides and peptidomimetics, new asparagine-based mono- and disaccharides containing glycopeptides were prepared in solution. The applicability of two common peptide coupling reagents, using an orthogonal Fmoc/t-Bu strategy along with acetyl protecting groups for the carbohydrate moiety, was studied. Thus, the prepared libraries of glycopeptides were designed as model systems of cell surfaces for future investigations by combined preparative mass spectroscopy and scanning tunneling microscopy (STM) using soft-landing electrospray beam deposition (ES-IBD), on metal surfaces.
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spelling pubmed-72148772020-05-26 Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations Sršan, Laura Ziegler, Thomas Beilstein J Org Chem Full Research Paper For investigations on the biological functions of oligosaccharides and peptidomimetics, new asparagine-based mono- and disaccharides containing glycopeptides were prepared in solution. The applicability of two common peptide coupling reagents, using an orthogonal Fmoc/t-Bu strategy along with acetyl protecting groups for the carbohydrate moiety, was studied. Thus, the prepared libraries of glycopeptides were designed as model systems of cell surfaces for future investigations by combined preparative mass spectroscopy and scanning tunneling microscopy (STM) using soft-landing electrospray beam deposition (ES-IBD), on metal surfaces. Beilstein-Institut 2020-04-30 /pmc/articles/PMC7214877/ /pubmed/32461770 http://dx.doi.org/10.3762/bjoc.16.80 Text en Copyright © 2020, Sršan and Ziegler https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Sršan, Laura
Ziegler, Thomas
Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations
title Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations
title_full Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations
title_fullStr Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations
title_full_unstemmed Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations
title_short Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations
title_sort synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214877/
https://www.ncbi.nlm.nih.gov/pubmed/32461770
http://dx.doi.org/10.3762/bjoc.16.80
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