Cargando…

Tetramethylpyrazine Induces Apoptosis and Inhibits Proliferation of Hypertrophic Scar-Derived Fibroblasts via Inhibiting the Phosphorylation of AKT

Hypertrophic scar (HS) is a serious fibrotic skin disease and often considered as a kind of benign skin tumor. Tetramethylpyrazine (TMP), the main chemical composition of the traditional Chinese medicine Chuanxiong Rhizoma, has shown significant clinical benefits in the treatment of fibrosis disease...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Xue, Wang, Zheng, Wu, Gaofeng, Xu, Xiaofan, Zhang, Jian, Li, Yan, Zhang, Hong, Guo, Shuzhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214921/ https://www.ncbi.nlm.nih.gov/pubmed/32431617 http://dx.doi.org/10.3389/fphar.2020.00602

Ejemplares similares

Tetramethylpyrazine Enhances the Antitumor Effect of Paclitaxel by Inhibiting Angiogenesis and Inducing Apoptosis
por: Zou, Liang, et al.
Publicado: (2019)

Adipose-Derived Mesenchymal Stem Cells Alleviate Hypertrophic Scar by Inhibiting Bioactivity and Inducing Apoptosis in Hypertrophic Scar Fibroblasts
por: Li, Shiyi, et al.
Publicado: (2022)

ABT-263 Reduces Hypertrophic Scars by Targeting Apoptosis of Myofibroblasts
por: Yang, Xiaolan, et al.
Publicado: (2021)

Platycodin D inhibits the proliferation and migration of hypertrophic scar-derived fibroblasts and promotes apoptosis through a caspase-dependent pathway
por: Yu, Zhencheng, et al.
Publicado: (2022)

Development of a Porcine Full-Thickness Burn Hypertrophic Scar Model and Investigation of the Effects of Shikonin on Hypertrophic Scar Remediation
por: Deng, Xingwang, et al.
Publicado: (2018)

Oxymatrine promotes hypertrophic scar repair through reduced human scar fibroblast viability, collagen and induced apoptosis via autophagy inhibition
por: Deng, Xingwang, et al.
Publicado: (2021)

Targeted apoptosis of myofibroblasts by elesclomol inhibits hypertrophic scar formation
por: Feng, Yi, et al.
Publicado: (2020)

miR-495 inhibits the growth of fibroblasts in hypertrophic scars
por: Guo, Bingyu, et al.
Publicado: (2019)

Extracellular vesicles from Lactobacillus druckerii inhibit hypertrophic scar fibrosis
por: Han, Fu, et al.
Publicado: (2023)

Inhibition of sphingosine kinase 2 attenuates hypertrophic scar formation via upregulation of Smad7 in human hypertrophic scar fibroblasts
por: Zeng, Jian, et al.
Publicado: (2020)

The Akt/FoxO/p27(Kip1) axis contributes to the anti‐proliferation of pentoxifylline in hypertrophic scars
por: Yang, Fangfang, et al.
Publicado: (2019)

MicroRNA-9-5p inhibits proliferation and induces apoptosis of human hypertrophic scar fibroblasts through targeting peroxisome proliferator-activated receptor β
por: Chai, Chi-Yung, et al.
Publicado: (2020)

Tetramethylpyrazine inhibits proliferation of colon cancer cells in vitro
por: Li, Hua, et al.
Publicado: (2021)

Tetramethylpyrazine: A Review of Its Antitumor Potential and Mechanisms
por: Yang, Shaojie, et al.
Publicado: (2021)

A novel lncRNA FPASL regulates fibroblast proliferation via the PI3K/AKT and MAPK signaling pathways in hypertrophic scar: FPASL regulates hypertrophic scar via the AKT and MAPK pathways
por: Ma, Fang, et al.
Publicado: (2022)

Shikonin promotes hypertrophic scar repair by autophagy of hypertrophic scar-derived fibroblasts
por: Zhang, Qing, et al.
Publicado: (2023)

Nephroprotective Effects of Tetramethylpyrazine Nitrone TBN in Diabetic Kidney Disease
por: Jing, Mei, et al.
Publicado: (2021)

AKT Inhibitor SC66 Inhibits Proliferation and Induces Apoptosis in Human Glioblastoma Through Down-Regulating AKT/β-Catenin Pathway
por: Gao, Lun, et al.
Publicado: (2020)

Targeting HSP90 Inhibits Proliferation and Induces Apoptosis Through AKT1/ERK Pathway in Lung Cancer
por: Niu, Mengyuan, et al.
Publicado: (2022)

Artesunate, as an Hsp90 inhibitor, inhibits the proliferation of Burkitt’s lymphoma cells by inhibiting AKT and ERK
por: Yuan-Ce, Li, et al.
Publicado: (2023)

Lycorine Inhibits Hypertrophic Scar Formation by Inducing ROS-Mediated Apoptosis
por: Dong, Yunxian, et al.
Publicado: (2022)

MicroRNA-182-5p Inhibits Hypertrophic Scar Formation by Inhibiting the Proliferation and Migration of Fibroblasts via SMAD4 Pathway
por: Jin, Mingzhu, et al.
Publicado: (2023)

Cuprous oxide nanoparticles reduces hypertrophic scarring by inducing fibroblast apoptosis
por: Xiao, Yongqiang, et al.
Publicado: (2019)

Therapeutic Strategies by Regulating Interleukin Family to Suppress Inflammation in Hypertrophic Scar and Keloid
por: Zhang, Dan, et al.
Publicado: (2021)

Regulatory mechanisms of tetramethylpyrazine on central nervous system diseases: A review
por: Liu, Yue, et al.
Publicado: (2022)

Adipose-derived mesenchymal stem cells inhibit cell proliferation and migration and suppress extracellular matrix synthesis in hypertrophic-scar and keloid fibroblasts
por: Xie, Fang, et al.
Publicado: (2021)

miR-181b-5p promotes proliferation and inhibits apoptosis of hypertrophic scar fibroblasts through regulating the MEK/ERK/p21 pathway
por: Liu, Bo, et al.
Publicado: (2019)

MicroRNA-98 inhibits the cell proliferation of human hypertrophic scar fibroblasts via targeting Col1A1
por: Bi, Sheng, et al.
Publicado: (2017)

Traditional Chinese medicine for hypertrophic scars—A review of the therapeutic methods and potential effects
por: Chen, Daqin, et al.
Publicado: (2022)

miR-211-5p inhibits the proliferation, migration, invasion, and induces apoptosis of human hypertrophic scar fibroblasts by regulating TGFβR2 expression
por: Tang, Jun, et al.
Publicado: (2021)

TSG‐6 inhibits hypertrophic scar fibroblast proliferation by regulating IRE1α/TRAF2/NF‐κB signalling
por: Ma, Li, et al.
Publicado: (2022)

Magnetic Resonance Imaging Investigation of Neuroplasticity After Ischemic Stroke in Tetramethylpyrazine-Treated Rats
por: Feng, Xue-Feng, et al.
Publicado: (2022)

PSTPIP2 Inhibits the Inflammatory Response and Proliferation of Fibroblast-Like Synoviocytes in vitro
por: Yao, Yao, et al.
Publicado: (2018)

Tetramethylpyrazine Ameliorates Peritoneal Angiogenesis by Regulating VEGF/Hippo/YAP Signaling
por: Zhu, Xiaolin, et al.
Publicado: (2021)

Erratum to miR-211-5p inhibits the proliferation, migration, invasion, and induces apoptosis of human hypertrophic scar fibroblasts by regulating TGFβR2 expression
Publicado: (2023)

Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer’s disease mouse model and proteomics analysis
por: Zhou, Xinhua, et al.
Publicado: (2023)

α-Mangostin Induces Apoptosis and Inhibits Metastasis of Breast Cancer Cells via Regulating RXRα-AKT Signaling Pathway
por: Zhu, Xiuzhi, et al.
Publicado: (2021)

The mechanisms of action of mitochondrial targeting agents in cancer: inhibiting oxidative phosphorylation and inducing apoptosis
por: Yang, Yi, et al.
Publicado: (2023)

A Danshensu-Tetramethylpyrazine Conjugate DT-010 Overcomes Multidrug Resistance in Human Breast Cancer
por: Zhou, Xinhua, et al.
Publicado: (2019)

Tetramethylpyrazine nitrone activates hypoxia-inducible factor and regulates iron homeostasis to improve renal anemia
por: Cen, Yun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2eu76r85dampo0ef6q943pd4nm