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Regulation of Vessel Permeability by TRP Channels
The vascular endothelium constitutes a semi-permeable barrier between blood and interstitial fluids. Since an augmented endothelial permeability is often associated to pathological states, understanding the molecular basis for its regulation is a crucial biomedical and clinical challenge. This revie...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214926/ https://www.ncbi.nlm.nih.gov/pubmed/32431625 http://dx.doi.org/10.3389/fphys.2020.00421 |
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author | Genova, Tullio Gaglioti, Deborah Munaron, Luca |
author_facet | Genova, Tullio Gaglioti, Deborah Munaron, Luca |
author_sort | Genova, Tullio |
collection | PubMed |
description | The vascular endothelium constitutes a semi-permeable barrier between blood and interstitial fluids. Since an augmented endothelial permeability is often associated to pathological states, understanding the molecular basis for its regulation is a crucial biomedical and clinical challenge. This review focuses on the processes controlling paracellular permeability that is the permeation of fluids between adjacent endothelial cells (ECs). Cytosolic calcium changes are often detected as early events preceding the alteration of the endothelial barrier (EB) function. For this reason, great interest has been devoted in the last decades to unveil the molecular mechanisms underlying calcium fluxes and their functional relationship with vessel permeability. Beyond the dicotomic classification between store-dependent and independent calcium entry at the plasma membrane level, the search for the molecular components of the related calcium-permeable channels revealed a difficult task for intrinsic and technical limitations. The contribution of redundant channel-forming proteins including members of TRP superfamily and Orai1, together with the very complex intracellular modulatory pathways, displays a huge variability among tissues and along the vascular tree. Moreover, calcium-independent events could significantly concur to the regulation of vascular permeability in an intricate and fascinating multifactorial framework. |
format | Online Article Text |
id | pubmed-7214926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72149262020-05-19 Regulation of Vessel Permeability by TRP Channels Genova, Tullio Gaglioti, Deborah Munaron, Luca Front Physiol Physiology The vascular endothelium constitutes a semi-permeable barrier between blood and interstitial fluids. Since an augmented endothelial permeability is often associated to pathological states, understanding the molecular basis for its regulation is a crucial biomedical and clinical challenge. This review focuses on the processes controlling paracellular permeability that is the permeation of fluids between adjacent endothelial cells (ECs). Cytosolic calcium changes are often detected as early events preceding the alteration of the endothelial barrier (EB) function. For this reason, great interest has been devoted in the last decades to unveil the molecular mechanisms underlying calcium fluxes and their functional relationship with vessel permeability. Beyond the dicotomic classification between store-dependent and independent calcium entry at the plasma membrane level, the search for the molecular components of the related calcium-permeable channels revealed a difficult task for intrinsic and technical limitations. The contribution of redundant channel-forming proteins including members of TRP superfamily and Orai1, together with the very complex intracellular modulatory pathways, displays a huge variability among tissues and along the vascular tree. Moreover, calcium-independent events could significantly concur to the regulation of vascular permeability in an intricate and fascinating multifactorial framework. Frontiers Media S.A. 2020-05-05 /pmc/articles/PMC7214926/ /pubmed/32431625 http://dx.doi.org/10.3389/fphys.2020.00421 Text en Copyright © 2020 Genova, Gaglioti and Munaron. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Genova, Tullio Gaglioti, Deborah Munaron, Luca Regulation of Vessel Permeability by TRP Channels |
title | Regulation of Vessel Permeability by TRP Channels |
title_full | Regulation of Vessel Permeability by TRP Channels |
title_fullStr | Regulation of Vessel Permeability by TRP Channels |
title_full_unstemmed | Regulation of Vessel Permeability by TRP Channels |
title_short | Regulation of Vessel Permeability by TRP Channels |
title_sort | regulation of vessel permeability by trp channels |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214926/ https://www.ncbi.nlm.nih.gov/pubmed/32431625 http://dx.doi.org/10.3389/fphys.2020.00421 |
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