Combining data integration and molecular dynamics for target identification in α-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1)

Parkinson’s disease (PD), Alzheimer’s disease (AD) and Amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases hallmarked by the formation of toxic protein aggregates. However, targeting these aggregates therapeutically have thus far shown no success. The treatment of AD has remained part...

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Detalles Bibliográficos
Autores principales: Jenkins, Kirsten, Mateeva, Teodora, Szabó, István, Melnik, Andre, Picotti, Paola, Csikász-Nagy, Attila, Rosta, Edina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215115/
https://www.ncbi.nlm.nih.gov/pubmed/32419904
http://dx.doi.org/10.1016/j.csbj.2020.04.010

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