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Novel coronavirus disease 2019 (COVID-19): relationship between chest CT scores and laboratory parameters

PURPOSE: To quantify the severity of 2019 novel coronavirus disease (COVID-19) on chest CT and to determine its relationship with laboratory parameters. METHODS: Patients with real-time fluorescence polymerase chain reaction (RT-PCR)–confirmed COVID-19 between January 01 and February 18, 2020, were...

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Autores principales: Zhang, Bin, Zhang, Jue, Chen, Hui, Chen, Luyan, Chen, Qiuying, Li, Minmin, Chen, Zhuozhi, You, Jingjing, Yang, Ke, Zhang, Shuixing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215122/
https://www.ncbi.nlm.nih.gov/pubmed/32399620
http://dx.doi.org/10.1007/s00259-020-04854-3
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author Zhang, Bin
Zhang, Jue
Chen, Hui
Chen, Luyan
Chen, Qiuying
Li, Minmin
Chen, Zhuozhi
You, Jingjing
Yang, Ke
Zhang, Shuixing
author_facet Zhang, Bin
Zhang, Jue
Chen, Hui
Chen, Luyan
Chen, Qiuying
Li, Minmin
Chen, Zhuozhi
You, Jingjing
Yang, Ke
Zhang, Shuixing
author_sort Zhang, Bin
collection PubMed
description PURPOSE: To quantify the severity of 2019 novel coronavirus disease (COVID-19) on chest CT and to determine its relationship with laboratory parameters. METHODS: Patients with real-time fluorescence polymerase chain reaction (RT-PCR)–confirmed COVID-19 between January 01 and February 18, 2020, were included in this study. Laboratory parameters were retrospectively collected from medical records. Severity of lung changes on chest CT of early, progressive, peak, and absorption stages was scored according to the percentage of lung involvement (5 lobes, scores 1–5 for each lobe, range 0–20). Relationship between CT scores and laboratory parameters was evaluated by the Spearman rank correlation. The Bonferroni correction adjusted significance level was at 0.05/4 = 0.0125. RESULTS: A total of 84 patients (mean age, 47.8 ± 12.0 years [standard deviation]; age range, 24–80 years) were evaluated. The patients underwent a total of 339 chest CT scans with a median interval of 4 days (interquartile range, 3–5 days). Median chest CT scores peaked at 4 days after the beginning of treatment and then declined. CT score of the early stage was correlated with neutrophil count (r = 0.531, P = 0.011). CT score of the progressive stage was correlated with neutrophil count (r = 0.502, P < 0.001), white blood cell count (r = 0.414, P = 0.001), C-reactive protein (r = 0.511, P < 0.001), procalcitonin (r = 0.423, P = 0.004), and lactose dehydrogenase (r = 0.369, P = 0.010). However, CT scores of the peak and absorption stages were not correlated with any parameter (P > 0.0125). No sex difference occurred regarding CT score (P > 0.05). CONCLUSION: Severity of lung abnormalities quantified on chest CT might correlate with laboratory parameters in the early and progressive stages. However, larger cohort studies are necessary.
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spelling pubmed-72151222020-05-12 Novel coronavirus disease 2019 (COVID-19): relationship between chest CT scores and laboratory parameters Zhang, Bin Zhang, Jue Chen, Hui Chen, Luyan Chen, Qiuying Li, Minmin Chen, Zhuozhi You, Jingjing Yang, Ke Zhang, Shuixing Eur J Nucl Med Mol Imaging Original Article PURPOSE: To quantify the severity of 2019 novel coronavirus disease (COVID-19) on chest CT and to determine its relationship with laboratory parameters. METHODS: Patients with real-time fluorescence polymerase chain reaction (RT-PCR)–confirmed COVID-19 between January 01 and February 18, 2020, were included in this study. Laboratory parameters were retrospectively collected from medical records. Severity of lung changes on chest CT of early, progressive, peak, and absorption stages was scored according to the percentage of lung involvement (5 lobes, scores 1–5 for each lobe, range 0–20). Relationship between CT scores and laboratory parameters was evaluated by the Spearman rank correlation. The Bonferroni correction adjusted significance level was at 0.05/4 = 0.0125. RESULTS: A total of 84 patients (mean age, 47.8 ± 12.0 years [standard deviation]; age range, 24–80 years) were evaluated. The patients underwent a total of 339 chest CT scans with a median interval of 4 days (interquartile range, 3–5 days). Median chest CT scores peaked at 4 days after the beginning of treatment and then declined. CT score of the early stage was correlated with neutrophil count (r = 0.531, P = 0.011). CT score of the progressive stage was correlated with neutrophil count (r = 0.502, P < 0.001), white blood cell count (r = 0.414, P = 0.001), C-reactive protein (r = 0.511, P < 0.001), procalcitonin (r = 0.423, P = 0.004), and lactose dehydrogenase (r = 0.369, P = 0.010). However, CT scores of the peak and absorption stages were not correlated with any parameter (P > 0.0125). No sex difference occurred regarding CT score (P > 0.05). CONCLUSION: Severity of lung abnormalities quantified on chest CT might correlate with laboratory parameters in the early and progressive stages. However, larger cohort studies are necessary. Springer Berlin Heidelberg 2020-05-12 2020 /pmc/articles/PMC7215122/ /pubmed/32399620 http://dx.doi.org/10.1007/s00259-020-04854-3 Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Zhang, Bin
Zhang, Jue
Chen, Hui
Chen, Luyan
Chen, Qiuying
Li, Minmin
Chen, Zhuozhi
You, Jingjing
Yang, Ke
Zhang, Shuixing
Novel coronavirus disease 2019 (COVID-19): relationship between chest CT scores and laboratory parameters
title Novel coronavirus disease 2019 (COVID-19): relationship between chest CT scores and laboratory parameters
title_full Novel coronavirus disease 2019 (COVID-19): relationship between chest CT scores and laboratory parameters
title_fullStr Novel coronavirus disease 2019 (COVID-19): relationship between chest CT scores and laboratory parameters
title_full_unstemmed Novel coronavirus disease 2019 (COVID-19): relationship between chest CT scores and laboratory parameters
title_short Novel coronavirus disease 2019 (COVID-19): relationship between chest CT scores and laboratory parameters
title_sort novel coronavirus disease 2019 (covid-19): relationship between chest ct scores and laboratory parameters
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215122/
https://www.ncbi.nlm.nih.gov/pubmed/32399620
http://dx.doi.org/10.1007/s00259-020-04854-3
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