Cargando…

Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors

BACKGROUND & AIMS: In patients with autoimmune atrophic gastritis and achlorhydria, hypergastrinemia is associated with the development of type 1 gastric neuroendocrine tumors (gNETs). Twelve months of treatment with netazepide (YF476), an antagonist of the cholecystokinin B receptor (CCKBR or C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lloyd, Katie A., Parsons, Bryony N., Burkitt, Michael D., Moore, Andrew R., Papoutsopoulou, Stamatia, Boyce, Malcolm, Duckworth, Carrie A., Exarchou, Klaire, Howes, Nathan, Rainbow, Lucille, Fang, Yongxiang, Oxvig, Claus, Dodd, Steven, Varro, Andrea, Hall, Neil, Pritchard, D. Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215182/ https://www.ncbi.nlm.nih.gov/pubmed/32004755 http://dx.doi.org/10.1016/j.jcmgh.2020.01.010

Ejemplares similares

Netazepide, a Gastrin Receptor Antagonist, Normalises Tumour Biomarkers and Causes Regression of Type 1 Gastric Neuroendocrine Tumours in a Nonrandomised Trial of Patients with Chronic Atrophic Gastritis
por: Moore, Andrew R., et al.
Publicado: (2013)

Correction: Netazepide, a Gastrin Receptor Antagonist, Normalises Tumour Biomarkers and Causes Regression of Type 1 Gastric Neuroendocrine Tumours in a Nonrandomised Trial of Patients with Chronic Atrophic Gastritis
por: Moore, Andrew R., et al.
Publicado: (2013)

New Developments in Gastric Neuroendocrine Neoplasms
por: Exarchou, Klaire, et al.
Publicado: (2022)

Lactation opposes pappalysin‐1‐driven pregnancy‐associated breast cancer
por: Takabatake, Yukie, et al.
Publicado: (2016)

Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use
por: Parsons, Bryony N., et al.
Publicado: (2017)

Endoscopic surveillance alone is feasible and safe in type I gastric neuroendocrine neoplasms less than 10 mm in diameter
por: Exarchou, Klaire, et al.
Publicado: (2022)

Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases
por: Guevara, Tibisay, et al.
Publicado: (2020)

Leptolysin, a Leptospira secreted metalloprotease of the pappalysin family with broad-spectrum activity
por: Courrol, Daniella dos Santos, et al.
Publicado: (2022)

Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27(kip1)
por: Lloyd, Katie A., et al.
Publicado: (2016)

Identification of Conserved Pappalysin 1-Derived Circular RNA-Mediated Competing Endogenous RNA in Osteosarcoma
por: Ming, Guang-Fu, et al.
Publicado: (2021)

Pappalysin-1 T cell receptor transgenic allo-restricted T cells kill Ewing sarcoma in vitro and in vivo
por: Kirschner, Andreas, et al.
Publicado: (2017)

Interleukin-10 Deficiency Impacts on TNF-Induced NFκB Regulated Responses In Vivo
por: Papoutsopoulou, Stamatia, et al.
Publicado: (2022)

EWS-FLI-1 creates a cell surface microenvironment conducive to IGF signaling by inducing pappalysin-1
por: Jayabal, Panneerselvam, et al.
Publicado: (2017)

Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models
por: Burkitt, Michael D., et al.
Publicado: (2017)

Signaling mediated by the NF-κB sub-units NF-κB1, NF-κB2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice
por: Burkitt, M D, et al.
Publicado: (2013)

Author Correction: Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration
por: Burkitt, M. D., et al.
Publicado: (2019)

Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease
por: Lloyd, Katie, et al.
Publicado: (2020)

Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa
por: Papoutsopoulou, Stamatia, et al.
Publicado: (2022)

Long-Term Iron Deficiency and Dietary Iron Excess Exacerbate Acute Dextran Sodium Sulphate-Induced Colitis and Are Associated with Significant Dysbiosis
por: Mahalhal, Awad, et al.
Publicado: (2021)

Recharacterization data for a geriatric gastrin polycolonal antibody
por: Dodd, Steven, et al.
Publicado: (2019)

Parkinson’s Disease, It Takes Guts: The Correlation between Intestinal Microbiome and Cytokine Network with Neurodegeneration
por: Xiromerisiou, Georgia, et al.
Publicado: (2023)

Soluble Non-Starch Polysaccharides From Plantain (Musa x paradisiaca L.) Diminish Epithelial Impact of Clostridioides difficile
por: Simpson, Hannah L., et al.
Publicado: (2021)

Can harmonisation of outcomes bridge the translation gap for pre-clinical research? A systematic review of outcomes measured in mouse models of type 2 diabetes
por: Harman, Nicola L., et al.
Publicado: (2020)

A knockin mouse model for human ATP4a(R703C) mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies
por: Calvete, Oriol, et al.
Publicado: (2016)

Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients
por: Papoutsopoulou, Stamatia, et al.
Publicado: (2019)

Epithelial Cell Shedding and Barrier Function: A Matter of Life and Death at the Small Intestinal Villus Tip
por: Williams, J. M., et al.
Publicado: (2015)

bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice
por: Duckworth, C. A., et al.
Publicado: (2015)

The Generation of an Engineered Interleukin-10 Protein With Improved Stability and Biological Function
por: Minshawi, Faisal, et al.
Publicado: (2020)

Oral iron exacerbates colitis and influences the intestinal microbiome
por: Mahalhal, Awad, et al.
Publicado: (2018)

Human TNF-Luc reporter mouse: A new model to quantify inflammatory responses
por: Minshawi, Faisal, et al.
Publicado: (2019)

TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages
por: Blair, Louise, et al.
Publicado: (2022)

NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells
por: Jones, Lauren G., et al.
Publicado: (2019)

NF‐κB1, NF‐κB2 and c‐Rel differentially regulate susceptibility to colitis‐associated adenoma development in C57BL/6 mice
por: Burkitt, Michael D, et al.
Publicado: (2015)

Peripheral Inflammatory Markers TNF-α and CCL2 Revisited: Association with Parkinson’s Disease Severity
por: Xiromerisiou, Georgia, et al.
Publicado: (2022)

Long‐term demographic decline and late glacial divergence in a Californian paleoendemic: Sequoiadendron giganteum (giant sequoia)
por: Dodd, Richard S., et al.
Publicado: (2016)

Association of genetic and climatic variability in giant sequoia, Sequoiadendron giganteum, reveals signatures of local adaptation along moisture‐related gradients
por: DeSilva, Rainbow, et al.
Publicado: (2020)

IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell–dependent antigen
por: Jacque, Emilie, et al.
Publicado: (2014)

Electrical measurements
por: Harris, Forest Klaire
Publicado: (1952)

Electrical measurements
por: Harris, Forest Klaire
Publicado: (1956)

A potpourri of pediatric urology
por: Farrugia, Marie-Klaire
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_rgnmu3t6ikp635t39r64bnujm3