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Acute and subchronic toxicity study of nonpolar extract of licorice roots in mice

Licorice is used as a medicinal plant, and several studies have shown that licorice has beneficial effects. The objective of this study was to evaluate the safety of nonpolar licorice extract using toxicity experiments. Nonpolar extract from the root of Glycyrrhiza uralensis (NERG) was analyzed by h...

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Autores principales: Kim, Hyun‐Yong, Zuo, Guanglei, Lee, Soo Kyeong, Lim, Soon Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215212/
https://www.ncbi.nlm.nih.gov/pubmed/32405381
http://dx.doi.org/10.1002/fsn3.1465
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author Kim, Hyun‐Yong
Zuo, Guanglei
Lee, Soo Kyeong
Lim, Soon Sung
author_facet Kim, Hyun‐Yong
Zuo, Guanglei
Lee, Soo Kyeong
Lim, Soon Sung
author_sort Kim, Hyun‐Yong
collection PubMed
description Licorice is used as a medicinal plant, and several studies have shown that licorice has beneficial effects. The objective of this study was to evaluate the safety of nonpolar licorice extract using toxicity experiments. Nonpolar extract from the root of Glycyrrhiza uralensis (NERG) was analyzed by high‐performance liquid chromatography (HPLC). Antioxidant ability was determined by method of TPC and DPPH. Blood pressure was monitored by using blood pressure meter. In the acute study, a single dose (2,000 mg/kg) was orally administered to mice. In the subchronic study, mice were treated with extract at doses (50, 100, 500, and 1,000 mg/kg) for 120 days. Significantly difference was not shown at blood pressure, hematological, and biochemical parameters, and histopathology on mice. The results suggested that at acute and subchronic toxicity, each levels of nonpolar licorice extract administration in experiments did not cause toxicity effects or death on mice.
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spelling pubmed-72152122020-05-13 Acute and subchronic toxicity study of nonpolar extract of licorice roots in mice Kim, Hyun‐Yong Zuo, Guanglei Lee, Soo Kyeong Lim, Soon Sung Food Sci Nutr Original Research Licorice is used as a medicinal plant, and several studies have shown that licorice has beneficial effects. The objective of this study was to evaluate the safety of nonpolar licorice extract using toxicity experiments. Nonpolar extract from the root of Glycyrrhiza uralensis (NERG) was analyzed by high‐performance liquid chromatography (HPLC). Antioxidant ability was determined by method of TPC and DPPH. Blood pressure was monitored by using blood pressure meter. In the acute study, a single dose (2,000 mg/kg) was orally administered to mice. In the subchronic study, mice were treated with extract at doses (50, 100, 500, and 1,000 mg/kg) for 120 days. Significantly difference was not shown at blood pressure, hematological, and biochemical parameters, and histopathology on mice. The results suggested that at acute and subchronic toxicity, each levels of nonpolar licorice extract administration in experiments did not cause toxicity effects or death on mice. John Wiley and Sons Inc. 2020-04-08 /pmc/articles/PMC7215212/ /pubmed/32405381 http://dx.doi.org/10.1002/fsn3.1465 Text en © 2020 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Kim, Hyun‐Yong
Zuo, Guanglei
Lee, Soo Kyeong
Lim, Soon Sung
Acute and subchronic toxicity study of nonpolar extract of licorice roots in mice
title Acute and subchronic toxicity study of nonpolar extract of licorice roots in mice
title_full Acute and subchronic toxicity study of nonpolar extract of licorice roots in mice
title_fullStr Acute and subchronic toxicity study of nonpolar extract of licorice roots in mice
title_full_unstemmed Acute and subchronic toxicity study of nonpolar extract of licorice roots in mice
title_short Acute and subchronic toxicity study of nonpolar extract of licorice roots in mice
title_sort acute and subchronic toxicity study of nonpolar extract of licorice roots in mice
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215212/
https://www.ncbi.nlm.nih.gov/pubmed/32405381
http://dx.doi.org/10.1002/fsn3.1465
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