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Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study
STUDY OBJECTIVES: To examine the association between sleep duration trajectories over 28 years and measures of cognition, gray matter volume, and white matter microstructure. We hypothesize that consistently meeting sleep guidelines that recommend at least 7 hours of sleep per night will be associat...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215267/ https://www.ncbi.nlm.nih.gov/pubmed/31904084 http://dx.doi.org/10.1093/sleep/zsz290 |
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author | Zitser, Jennifer Anatürk, Melis Zsoldos, Enikő Mahmood, Abda Filippini, Nicola Suri, Sana Leng, Yue Yaffe, Kristine Singh-Manoux, Archana Kivimaki, Mika Ebmeier, Klaus Sexton, Claire |
author_facet | Zitser, Jennifer Anatürk, Melis Zsoldos, Enikő Mahmood, Abda Filippini, Nicola Suri, Sana Leng, Yue Yaffe, Kristine Singh-Manoux, Archana Kivimaki, Mika Ebmeier, Klaus Sexton, Claire |
author_sort | Zitser, Jennifer |
collection | PubMed |
description | STUDY OBJECTIVES: To examine the association between sleep duration trajectories over 28 years and measures of cognition, gray matter volume, and white matter microstructure. We hypothesize that consistently meeting sleep guidelines that recommend at least 7 hours of sleep per night will be associated with better cognition, greater gray matter volumes, higher fractional anisotropy, and lower radial diffusivity values. METHODS: We studied 613 participants (age 42.3 ± 5.03 years at baseline) who self-reported sleep duration at five time points between 1985 and 2013, and who had cognitive testing and magnetic resonance imaging administered at a single timepoint between 2012 and 2016. We applied latent class growth analysis to estimate membership into trajectory groups based on self-reported sleep duration over time. Analysis of gray matter volumes was carried out using FSL Voxel-Based-Morphometry and white matter microstructure using Tract Based Spatial Statistics. We assessed group differences in cognitive and MRI outcomes using nonparametric permutation testing. RESULTS: Latent class growth analysis identified four trajectory groups, with an average sleep duration of 5.4 ± 0.2 hours (5%, N = 29), 6.2 ± 0.3 hours (37%, N = 228), 7.0 ± 0.2 hours (45%, N = 278), and 7.9 ± 0.3 hours (13%, N = 78). No differences in cognition, gray matter, and white matter measures were detected between groups. CONCLUSIONS: Our null findings suggest that current sleep guidelines that recommend at least 7 hours of sleep per night may not be supported in relation to an association between sleep patterns and cognitive function or brain structure. |
format | Online Article Text |
id | pubmed-7215267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-72152672020-05-15 Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study Zitser, Jennifer Anatürk, Melis Zsoldos, Enikő Mahmood, Abda Filippini, Nicola Suri, Sana Leng, Yue Yaffe, Kristine Singh-Manoux, Archana Kivimaki, Mika Ebmeier, Klaus Sexton, Claire Sleep Sleep, Health and Disease STUDY OBJECTIVES: To examine the association between sleep duration trajectories over 28 years and measures of cognition, gray matter volume, and white matter microstructure. We hypothesize that consistently meeting sleep guidelines that recommend at least 7 hours of sleep per night will be associated with better cognition, greater gray matter volumes, higher fractional anisotropy, and lower radial diffusivity values. METHODS: We studied 613 participants (age 42.3 ± 5.03 years at baseline) who self-reported sleep duration at five time points between 1985 and 2013, and who had cognitive testing and magnetic resonance imaging administered at a single timepoint between 2012 and 2016. We applied latent class growth analysis to estimate membership into trajectory groups based on self-reported sleep duration over time. Analysis of gray matter volumes was carried out using FSL Voxel-Based-Morphometry and white matter microstructure using Tract Based Spatial Statistics. We assessed group differences in cognitive and MRI outcomes using nonparametric permutation testing. RESULTS: Latent class growth analysis identified four trajectory groups, with an average sleep duration of 5.4 ± 0.2 hours (5%, N = 29), 6.2 ± 0.3 hours (37%, N = 228), 7.0 ± 0.2 hours (45%, N = 278), and 7.9 ± 0.3 hours (13%, N = 78). No differences in cognition, gray matter, and white matter measures were detected between groups. CONCLUSIONS: Our null findings suggest that current sleep guidelines that recommend at least 7 hours of sleep per night may not be supported in relation to an association between sleep patterns and cognitive function or brain structure. Oxford University Press 2020-01-06 /pmc/articles/PMC7215267/ /pubmed/31904084 http://dx.doi.org/10.1093/sleep/zsz290 Text en © Sleep Research Society 2020. Published by Oxford University Press [on behalf of the Sleep Research Society]. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Sleep, Health and Disease Zitser, Jennifer Anatürk, Melis Zsoldos, Enikő Mahmood, Abda Filippini, Nicola Suri, Sana Leng, Yue Yaffe, Kristine Singh-Manoux, Archana Kivimaki, Mika Ebmeier, Klaus Sexton, Claire Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study |
title | Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study |
title_full | Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study |
title_fullStr | Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study |
title_full_unstemmed | Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study |
title_short | Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study |
title_sort | sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study |
topic | Sleep, Health and Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215267/ https://www.ncbi.nlm.nih.gov/pubmed/31904084 http://dx.doi.org/10.1093/sleep/zsz290 |
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