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Association between Post-Diagnosis Particulate Matter Exposure among 5-Year Cancer Survivors and Cardiovascular Disease Risk in Three Metropolitan Areas from South Korea

Cancer survivors are at an increased risk for cardiovascular disease (CVD). However, the association between particulate matter (PM) and CVD risk among cancer survivors (alive >5 years since diagnosis) is unclear. We investigated the risk of CVD among 40,899 cancer survivors within the Korean Nat...

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Autores principales: Choi, Seulggie, Kim, Kyae Hyung, Kim, Kyuwoong, Chang, Jooyoung, Kim, Sung Min, Kim, Seong Rae, Cho, Yoosun, Lee, Gyeongsil, Son, Joung Sik, Park, Sang Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215375/
https://www.ncbi.nlm.nih.gov/pubmed/32326144
http://dx.doi.org/10.3390/ijerph17082841
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author Choi, Seulggie
Kim, Kyae Hyung
Kim, Kyuwoong
Chang, Jooyoung
Kim, Sung Min
Kim, Seong Rae
Cho, Yoosun
Lee, Gyeongsil
Son, Joung Sik
Park, Sang Min
author_facet Choi, Seulggie
Kim, Kyae Hyung
Kim, Kyuwoong
Chang, Jooyoung
Kim, Sung Min
Kim, Seong Rae
Cho, Yoosun
Lee, Gyeongsil
Son, Joung Sik
Park, Sang Min
author_sort Choi, Seulggie
collection PubMed
description Cancer survivors are at an increased risk for cardiovascular disease (CVD). However, the association between particulate matter (PM) and CVD risk among cancer survivors (alive >5 years since diagnosis) is unclear. We investigated the risk of CVD among 40,899 cancer survivors within the Korean National Health Insurance Service database. Exposure to PM was determined by assessing yearly average PM levels obtained from the Air Korea database from 2008 to 2011. PMs with sizes <2.5 (PM2.5), <10 (PM10), or 2.5–10 (PM2.5–10) μm in diameter were compared, with each PM level exposure further divided into quintiles. Patients were followed up from January 2012 to date of CVD event, death, or December 2017, whichever came earliest. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for CVD were calculated using Cox proportional hazards regression by PM exposure levels. Compared with cancer survivors in the lowest quintile of PM2.5 exposure, those within the highest quintile had a greater risk for CVD (aHR 1.31, 95% CI 1.07–1.59). Conversely, increasing PM10 and PM2.5–10 levels were not associated with increased CVD risk (p for trend 0.078 and 0.361, respectively). Cancer survivors who reduce PM2.5 exposure may benefit from lower risk of developing CVD.
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spelling pubmed-72153752020-05-18 Association between Post-Diagnosis Particulate Matter Exposure among 5-Year Cancer Survivors and Cardiovascular Disease Risk in Three Metropolitan Areas from South Korea Choi, Seulggie Kim, Kyae Hyung Kim, Kyuwoong Chang, Jooyoung Kim, Sung Min Kim, Seong Rae Cho, Yoosun Lee, Gyeongsil Son, Joung Sik Park, Sang Min Int J Environ Res Public Health Article Cancer survivors are at an increased risk for cardiovascular disease (CVD). However, the association between particulate matter (PM) and CVD risk among cancer survivors (alive >5 years since diagnosis) is unclear. We investigated the risk of CVD among 40,899 cancer survivors within the Korean National Health Insurance Service database. Exposure to PM was determined by assessing yearly average PM levels obtained from the Air Korea database from 2008 to 2011. PMs with sizes <2.5 (PM2.5), <10 (PM10), or 2.5–10 (PM2.5–10) μm in diameter were compared, with each PM level exposure further divided into quintiles. Patients were followed up from January 2012 to date of CVD event, death, or December 2017, whichever came earliest. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for CVD were calculated using Cox proportional hazards regression by PM exposure levels. Compared with cancer survivors in the lowest quintile of PM2.5 exposure, those within the highest quintile had a greater risk for CVD (aHR 1.31, 95% CI 1.07–1.59). Conversely, increasing PM10 and PM2.5–10 levels were not associated with increased CVD risk (p for trend 0.078 and 0.361, respectively). Cancer survivors who reduce PM2.5 exposure may benefit from lower risk of developing CVD. MDPI 2020-04-21 2020-04 /pmc/articles/PMC7215375/ /pubmed/32326144 http://dx.doi.org/10.3390/ijerph17082841 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choi, Seulggie
Kim, Kyae Hyung
Kim, Kyuwoong
Chang, Jooyoung
Kim, Sung Min
Kim, Seong Rae
Cho, Yoosun
Lee, Gyeongsil
Son, Joung Sik
Park, Sang Min
Association between Post-Diagnosis Particulate Matter Exposure among 5-Year Cancer Survivors and Cardiovascular Disease Risk in Three Metropolitan Areas from South Korea
title Association between Post-Diagnosis Particulate Matter Exposure among 5-Year Cancer Survivors and Cardiovascular Disease Risk in Three Metropolitan Areas from South Korea
title_full Association between Post-Diagnosis Particulate Matter Exposure among 5-Year Cancer Survivors and Cardiovascular Disease Risk in Three Metropolitan Areas from South Korea
title_fullStr Association between Post-Diagnosis Particulate Matter Exposure among 5-Year Cancer Survivors and Cardiovascular Disease Risk in Three Metropolitan Areas from South Korea
title_full_unstemmed Association between Post-Diagnosis Particulate Matter Exposure among 5-Year Cancer Survivors and Cardiovascular Disease Risk in Three Metropolitan Areas from South Korea
title_short Association between Post-Diagnosis Particulate Matter Exposure among 5-Year Cancer Survivors and Cardiovascular Disease Risk in Three Metropolitan Areas from South Korea
title_sort association between post-diagnosis particulate matter exposure among 5-year cancer survivors and cardiovascular disease risk in three metropolitan areas from south korea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215375/
https://www.ncbi.nlm.nih.gov/pubmed/32326144
http://dx.doi.org/10.3390/ijerph17082841
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