PDE2A Is Indispensable for Mouse Liver Development and Hematopoiesis

Phosphodiesterase 2A (PDE2A) is a cAMP-cGMP hydrolyzing enzyme essential for mouse development and the PDE2A knockout model (PDE2A(−/−)) is embryonic lethal. Notably, livers of PDE2A(−/−) embryos at embryonic day 14.5 (E14.5) have extremely reduced size. Morphological, cellular and molecular analyse...

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Detalles Bibliográficos
Autores principales: Barbagallo, Federica, Rotilio, Valentina, Assenza, Maria Rita, Aguanno, Salvatore, Orsini, Tiziana, Putti, Sabrina, Isidori, Andrea M., Lenzi, Andrea, Naro, Fabio, De Angelis, Luciana, Pellegrini, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215450/
https://www.ncbi.nlm.nih.gov/pubmed/32326334
http://dx.doi.org/10.3390/ijms21082902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215450/
https://www.ncbi.nlm.nih.gov/pubmed/32326334
http://dx.doi.org/10.3390/ijms21082902

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