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Estrogen Receptors and Endometriosis
Endometriosis is a frequent and chronic inflammatory disease with impacts on reproduction, health and quality of life. This disorder is highly estrogen-dependent and the purpose of hormonal treatments is to decrease the endogenous ovarian production of estrogens. High estrogen production is a consis...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215544/ https://www.ncbi.nlm.nih.gov/pubmed/32316608 http://dx.doi.org/10.3390/ijms21082815 |
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author | Chantalat, Elodie Valera, Marie-Cécile Vaysse, Charlotte Noirrit, Emmanuelle Rusidze, Mariam Weyl, Ariane Vergriete, Kelig Buscail, Etienne Lluel, Philippe Fontaine, Coralie Arnal, Jean-François Lenfant, Françoise |
author_facet | Chantalat, Elodie Valera, Marie-Cécile Vaysse, Charlotte Noirrit, Emmanuelle Rusidze, Mariam Weyl, Ariane Vergriete, Kelig Buscail, Etienne Lluel, Philippe Fontaine, Coralie Arnal, Jean-François Lenfant, Françoise |
author_sort | Chantalat, Elodie |
collection | PubMed |
description | Endometriosis is a frequent and chronic inflammatory disease with impacts on reproduction, health and quality of life. This disorder is highly estrogen-dependent and the purpose of hormonal treatments is to decrease the endogenous ovarian production of estrogens. High estrogen production is a consistently observed endocrine feature of endometriosis. mRNA and protein levels of estrogen receptors (ER) are different between a normal healthy endometrium and ectopic/eutopic endometrial lesions: endometriotic stromal cells express extraordinarily higher ERβ and significantly lower ERα levels compared with endometrial stromal cells. Aberrant epigenetic regulation such as DNA methylation in endometriotic cells is associated with the pathogenesis and development of endometriosis. Although there is a large body of data regarding ERs in endometriosis, our understanding of the roles of ERα and ERβ in the pathogenesis of endometriosis remains incomplete. The goal of this review is to provide an overview of the links between endometriosis, ERs and the recent advances of treatment strategies based on ERs modulation. We will also attempt to summarize the current understanding of the molecular and cellular mechanisms of action of ERs and how this could pave the way to new therapeutic strategies. |
format | Online Article Text |
id | pubmed-7215544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72155442020-05-22 Estrogen Receptors and Endometriosis Chantalat, Elodie Valera, Marie-Cécile Vaysse, Charlotte Noirrit, Emmanuelle Rusidze, Mariam Weyl, Ariane Vergriete, Kelig Buscail, Etienne Lluel, Philippe Fontaine, Coralie Arnal, Jean-François Lenfant, Françoise Int J Mol Sci Review Endometriosis is a frequent and chronic inflammatory disease with impacts on reproduction, health and quality of life. This disorder is highly estrogen-dependent and the purpose of hormonal treatments is to decrease the endogenous ovarian production of estrogens. High estrogen production is a consistently observed endocrine feature of endometriosis. mRNA and protein levels of estrogen receptors (ER) are different between a normal healthy endometrium and ectopic/eutopic endometrial lesions: endometriotic stromal cells express extraordinarily higher ERβ and significantly lower ERα levels compared with endometrial stromal cells. Aberrant epigenetic regulation such as DNA methylation in endometriotic cells is associated with the pathogenesis and development of endometriosis. Although there is a large body of data regarding ERs in endometriosis, our understanding of the roles of ERα and ERβ in the pathogenesis of endometriosis remains incomplete. The goal of this review is to provide an overview of the links between endometriosis, ERs and the recent advances of treatment strategies based on ERs modulation. We will also attempt to summarize the current understanding of the molecular and cellular mechanisms of action of ERs and how this could pave the way to new therapeutic strategies. MDPI 2020-04-17 /pmc/articles/PMC7215544/ /pubmed/32316608 http://dx.doi.org/10.3390/ijms21082815 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chantalat, Elodie Valera, Marie-Cécile Vaysse, Charlotte Noirrit, Emmanuelle Rusidze, Mariam Weyl, Ariane Vergriete, Kelig Buscail, Etienne Lluel, Philippe Fontaine, Coralie Arnal, Jean-François Lenfant, Françoise Estrogen Receptors and Endometriosis |
title | Estrogen Receptors and Endometriosis |
title_full | Estrogen Receptors and Endometriosis |
title_fullStr | Estrogen Receptors and Endometriosis |
title_full_unstemmed | Estrogen Receptors and Endometriosis |
title_short | Estrogen Receptors and Endometriosis |
title_sort | estrogen receptors and endometriosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215544/ https://www.ncbi.nlm.nih.gov/pubmed/32316608 http://dx.doi.org/10.3390/ijms21082815 |
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