COVID-19 and RAS: Unravelling an Unclear Relationship

The renin-angiotensin system (RAS) plays a main role in regulating blood pressure and electrolyte and liquid balance. Previous evidence suggests that RAS may represent an important target for the treatment of lung pathologies, especially for acute respiratory distress syndrome and chronic fibrotic d...

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Autores principales: D’Ardes, Damiano, Boccatonda, Andrea, Rossi, Ilaria, Guagnano, Maria Teresa, Santilli, Francesca, Cipollone, Francesco, Bucci, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215550/
https://www.ncbi.nlm.nih.gov/pubmed/32344526
http://dx.doi.org/10.3390/ijms21083003
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author D’Ardes, Damiano
Boccatonda, Andrea
Rossi, Ilaria
Guagnano, Maria Teresa
Santilli, Francesca
Cipollone, Francesco
Bucci, Marco
author_facet D’Ardes, Damiano
Boccatonda, Andrea
Rossi, Ilaria
Guagnano, Maria Teresa
Santilli, Francesca
Cipollone, Francesco
Bucci, Marco
author_sort D’Ardes, Damiano
collection PubMed
description The renin-angiotensin system (RAS) plays a main role in regulating blood pressure and electrolyte and liquid balance. Previous evidence suggests that RAS may represent an important target for the treatment of lung pathologies, especially for acute respiratory distress syndrome and chronic fibrotic disease. The scientific community has recently focused its attention on angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor 1 (AT1R) inhibitors and their possible benefit/harms for patients infected by Coronavirus disease (COVID-19) who experience pneumonia, but there are still some doubts about the effects of these drugs in this setting.
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spelling pubmed-72155502020-05-22 COVID-19 and RAS: Unravelling an Unclear Relationship D’Ardes, Damiano Boccatonda, Andrea Rossi, Ilaria Guagnano, Maria Teresa Santilli, Francesca Cipollone, Francesco Bucci, Marco Int J Mol Sci Commentary The renin-angiotensin system (RAS) plays a main role in regulating blood pressure and electrolyte and liquid balance. Previous evidence suggests that RAS may represent an important target for the treatment of lung pathologies, especially for acute respiratory distress syndrome and chronic fibrotic disease. The scientific community has recently focused its attention on angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor 1 (AT1R) inhibitors and their possible benefit/harms for patients infected by Coronavirus disease (COVID-19) who experience pneumonia, but there are still some doubts about the effects of these drugs in this setting. MDPI 2020-04-24 /pmc/articles/PMC7215550/ /pubmed/32344526 http://dx.doi.org/10.3390/ijms21083003 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
D’Ardes, Damiano
Boccatonda, Andrea
Rossi, Ilaria
Guagnano, Maria Teresa
Santilli, Francesca
Cipollone, Francesco
Bucci, Marco
COVID-19 and RAS: Unravelling an Unclear Relationship
title COVID-19 and RAS: Unravelling an Unclear Relationship
title_full COVID-19 and RAS: Unravelling an Unclear Relationship
title_fullStr COVID-19 and RAS: Unravelling an Unclear Relationship
title_full_unstemmed COVID-19 and RAS: Unravelling an Unclear Relationship
title_short COVID-19 and RAS: Unravelling an Unclear Relationship
title_sort covid-19 and ras: unravelling an unclear relationship
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215550/
https://www.ncbi.nlm.nih.gov/pubmed/32344526
http://dx.doi.org/10.3390/ijms21083003
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