Cargando…

Dental Amalgam Fillings and Multiple Sclerosis: A Nationwide Population-Based Case–Control Study in Taiwan

Multiple sclerosis (MS) is an inflammatory neurological disease characterized by autoimmune-mediated demyelination of the central nervous system. Genetic and environmental factors may contribute to the development of MS. This has not been confirmed yet. Dental amalgam has long been controversial in...

Descripción completa

Detalles Bibliográficos
Autores principales: Tseng, Chien-Fang, Chen, Kun-Huang, Yu, Hui-Chieh, Huang, Fu-Mei, Chang, Yu-Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215668/
https://www.ncbi.nlm.nih.gov/pubmed/32290568
http://dx.doi.org/10.3390/ijerph17082637
_version_ 1783532240309846016
author Tseng, Chien-Fang
Chen, Kun-Huang
Yu, Hui-Chieh
Huang, Fu-Mei
Chang, Yu-Chao
author_facet Tseng, Chien-Fang
Chen, Kun-Huang
Yu, Hui-Chieh
Huang, Fu-Mei
Chang, Yu-Chao
author_sort Tseng, Chien-Fang
collection PubMed
description Multiple sclerosis (MS) is an inflammatory neurological disease characterized by autoimmune-mediated demyelination of the central nervous system. Genetic and environmental factors may contribute to the development of MS. This has not been confirmed yet. Dental amalgam has long been controversial in MS due to its mercury content but the toxicological implications of mercury-containing amalgam fillings (AMF) for MS remain to be elucidated. We conducted a case–control study to investigate the association between AMF and the risk of MS from the Taiwanese National Health Insurance Research Database (NHIRD). Case (n = 612) and control (n = 612) groups were matched by sex, age, urbanization level, monthly income, and Charlson comorbidity index by propensity score matched with a 1:1 ratio from 2000 to 2013. Differences between cases and controls was not statistically significant (OR: 0.82, 95% CI = 0.65–1.05). In subjects stratified by gender, MS was also not associated with AMF for women (OR: 0.743, 95% CI = 0.552–1.000) and men (OR: 1.006, 95% CI = 0.670–1.509), respectively. In summary, this Taiwanese nationwide population-based case–control study did not find an association between MS and AMF.
format Online
Article
Text
id pubmed-7215668
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72156682020-05-22 Dental Amalgam Fillings and Multiple Sclerosis: A Nationwide Population-Based Case–Control Study in Taiwan Tseng, Chien-Fang Chen, Kun-Huang Yu, Hui-Chieh Huang, Fu-Mei Chang, Yu-Chao Int J Environ Res Public Health Article Multiple sclerosis (MS) is an inflammatory neurological disease characterized by autoimmune-mediated demyelination of the central nervous system. Genetic and environmental factors may contribute to the development of MS. This has not been confirmed yet. Dental amalgam has long been controversial in MS due to its mercury content but the toxicological implications of mercury-containing amalgam fillings (AMF) for MS remain to be elucidated. We conducted a case–control study to investigate the association between AMF and the risk of MS from the Taiwanese National Health Insurance Research Database (NHIRD). Case (n = 612) and control (n = 612) groups were matched by sex, age, urbanization level, monthly income, and Charlson comorbidity index by propensity score matched with a 1:1 ratio from 2000 to 2013. Differences between cases and controls was not statistically significant (OR: 0.82, 95% CI = 0.65–1.05). In subjects stratified by gender, MS was also not associated with AMF for women (OR: 0.743, 95% CI = 0.552–1.000) and men (OR: 1.006, 95% CI = 0.670–1.509), respectively. In summary, this Taiwanese nationwide population-based case–control study did not find an association between MS and AMF. MDPI 2020-04-12 2020-04 /pmc/articles/PMC7215668/ /pubmed/32290568 http://dx.doi.org/10.3390/ijerph17082637 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tseng, Chien-Fang
Chen, Kun-Huang
Yu, Hui-Chieh
Huang, Fu-Mei
Chang, Yu-Chao
Dental Amalgam Fillings and Multiple Sclerosis: A Nationwide Population-Based Case–Control Study in Taiwan
title Dental Amalgam Fillings and Multiple Sclerosis: A Nationwide Population-Based Case–Control Study in Taiwan
title_full Dental Amalgam Fillings and Multiple Sclerosis: A Nationwide Population-Based Case–Control Study in Taiwan
title_fullStr Dental Amalgam Fillings and Multiple Sclerosis: A Nationwide Population-Based Case–Control Study in Taiwan
title_full_unstemmed Dental Amalgam Fillings and Multiple Sclerosis: A Nationwide Population-Based Case–Control Study in Taiwan
title_short Dental Amalgam Fillings and Multiple Sclerosis: A Nationwide Population-Based Case–Control Study in Taiwan
title_sort dental amalgam fillings and multiple sclerosis: a nationwide population-based case–control study in taiwan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215668/
https://www.ncbi.nlm.nih.gov/pubmed/32290568
http://dx.doi.org/10.3390/ijerph17082637
work_keys_str_mv AT tsengchienfang dentalamalgamfillingsandmultiplesclerosisanationwidepopulationbasedcasecontrolstudyintaiwan
AT chenkunhuang dentalamalgamfillingsandmultiplesclerosisanationwidepopulationbasedcasecontrolstudyintaiwan
AT yuhuichieh dentalamalgamfillingsandmultiplesclerosisanationwidepopulationbasedcasecontrolstudyintaiwan
AT huangfumei dentalamalgamfillingsandmultiplesclerosisanationwidepopulationbasedcasecontrolstudyintaiwan
AT changyuchao dentalamalgamfillingsandmultiplesclerosisanationwidepopulationbasedcasecontrolstudyintaiwan