Pharmacological Inhibition of CA-IX Impairs Tumor Cell Proliferation, Migration and Invasiveness

Carbonic anhydrase IX (CA-IX) plays a pivotal role in regulation of pH in tumor milieu catalyzing carbonic acid formation by hydrating CO(2). An acidification of tumor microenvironment contributes to tumor progression via multiple processes, including reduced cell-cell adhesion, increased migration...

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Detalles Bibliográficos
Autores principales: Ciccone, Valerio, Filippelli, Arianna, Angeli, Andrea, Supuran, Claudiu T., Morbidelli, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215745/
https://www.ncbi.nlm.nih.gov/pubmed/32340282
http://dx.doi.org/10.3390/ijms21082983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215745/
https://www.ncbi.nlm.nih.gov/pubmed/32340282
http://dx.doi.org/10.3390/ijms21082983

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