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Pharmacological Inhibition of CA-IX Impairs Tumor Cell Proliferation, Migration and Invasiveness
Carbonic anhydrase IX (CA-IX) plays a pivotal role in regulation of pH in tumor milieu catalyzing carbonic acid formation by hydrating CO(2). An acidification of tumor microenvironment contributes to tumor progression via multiple processes, including reduced cell-cell adhesion, increased migration...
Autores principales: | Ciccone, Valerio, Filippelli, Arianna, Angeli, Andrea, Supuran, Claudiu T., Morbidelli, Lucia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215745/ https://www.ncbi.nlm.nih.gov/pubmed/32340282 http://dx.doi.org/10.3390/ijms21082983 |
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