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The Paradox Association between Smoking and Blood Pressure among Half Million Chinese People

Background: The association between smoking and blood pressure (BP) has been explored extensively, yet the results remain inconclusive. Using real-world evidence of a large Chinese population, we examine the effect of smoking on BP levels. Methods: We utilize half a million adults from the China Kad...

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Autores principales: Wang, Mengying, Li, Wenyong, Zhou, Ren, Wang, Siyue, Zheng, Hongchen, Jiang, Jin, Wang, Shengfeng, Yu, Canqing, Gao, Wenjing, Lv, Jun, Wu, Tao, Cao, Weihua, Hu, Yonghua, Li, Liming, Ji, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215755/
https://www.ncbi.nlm.nih.gov/pubmed/32325946
http://dx.doi.org/10.3390/ijerph17082824
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author Wang, Mengying
Li, Wenyong
Zhou, Ren
Wang, Siyue
Zheng, Hongchen
Jiang, Jin
Wang, Shengfeng
Yu, Canqing
Gao, Wenjing
Lv, Jun
Wu, Tao
Cao, Weihua
Hu, Yonghua
Li, Liming
Ji, John S.
author_facet Wang, Mengying
Li, Wenyong
Zhou, Ren
Wang, Siyue
Zheng, Hongchen
Jiang, Jin
Wang, Shengfeng
Yu, Canqing
Gao, Wenjing
Lv, Jun
Wu, Tao
Cao, Weihua
Hu, Yonghua
Li, Liming
Ji, John S.
author_sort Wang, Mengying
collection PubMed
description Background: The association between smoking and blood pressure (BP) has been explored extensively, yet the results remain inconclusive. Using real-world evidence of a large Chinese population, we examine the effect of smoking on BP levels. Methods: We utilize half a million adults from the China Kadoorie Biobank (CKB) study with baseline sampling collected between 2004 and 2008. Multivariable linear regression analyses are used to estimate linear regression coefficients of smoking for systolic blood pressure (SBP) and diastolic blood pressure (DBP). Results: 459,815 participants (180,236 males and 279,579 females) are included in the analysis. Regular smoking is significantly associated with lower SBP (−0.57 mm Hg, p < 0.001) and DBP (−0.35 mm Hg, p < 0.001) when compared with non-smoking in men. Additionally, SBP and DBP decrease significantly among all groups of different smoking status in women (p < 0.001). Additionally, pack-years show negative associations with SBP and DBP in both men and women. Further analysis shows the interaction of smoking and alcohol consumption is associated with an increase of SBP and DBP (men: 2.38 mm Hg and 0.89 mm Hg; women: 5.21 mm Hg and 2.62 mm Hg) among co-regular smokers and regular drinkers when compared with regular smokers who are not exposed to alcohol consumption. Conclusions: A negative association between smoking and BP is observed. However, the interaction between smoking and alcohol consumption is associated with BP increase. The findings suggest the importance of considering smoking and alcohol consumption in BP control in addition to antihypertensive treatment in clinical and public health practice.
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spelling pubmed-72157552020-05-22 The Paradox Association between Smoking and Blood Pressure among Half Million Chinese People Wang, Mengying Li, Wenyong Zhou, Ren Wang, Siyue Zheng, Hongchen Jiang, Jin Wang, Shengfeng Yu, Canqing Gao, Wenjing Lv, Jun Wu, Tao Cao, Weihua Hu, Yonghua Li, Liming Ji, John S. Int J Environ Res Public Health Article Background: The association between smoking and blood pressure (BP) has been explored extensively, yet the results remain inconclusive. Using real-world evidence of a large Chinese population, we examine the effect of smoking on BP levels. Methods: We utilize half a million adults from the China Kadoorie Biobank (CKB) study with baseline sampling collected between 2004 and 2008. Multivariable linear regression analyses are used to estimate linear regression coefficients of smoking for systolic blood pressure (SBP) and diastolic blood pressure (DBP). Results: 459,815 participants (180,236 males and 279,579 females) are included in the analysis. Regular smoking is significantly associated with lower SBP (−0.57 mm Hg, p < 0.001) and DBP (−0.35 mm Hg, p < 0.001) when compared with non-smoking in men. Additionally, SBP and DBP decrease significantly among all groups of different smoking status in women (p < 0.001). Additionally, pack-years show negative associations with SBP and DBP in both men and women. Further analysis shows the interaction of smoking and alcohol consumption is associated with an increase of SBP and DBP (men: 2.38 mm Hg and 0.89 mm Hg; women: 5.21 mm Hg and 2.62 mm Hg) among co-regular smokers and regular drinkers when compared with regular smokers who are not exposed to alcohol consumption. Conclusions: A negative association between smoking and BP is observed. However, the interaction between smoking and alcohol consumption is associated with BP increase. The findings suggest the importance of considering smoking and alcohol consumption in BP control in addition to antihypertensive treatment in clinical and public health practice. MDPI 2020-04-20 2020-04 /pmc/articles/PMC7215755/ /pubmed/32325946 http://dx.doi.org/10.3390/ijerph17082824 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Mengying
Li, Wenyong
Zhou, Ren
Wang, Siyue
Zheng, Hongchen
Jiang, Jin
Wang, Shengfeng
Yu, Canqing
Gao, Wenjing
Lv, Jun
Wu, Tao
Cao, Weihua
Hu, Yonghua
Li, Liming
Ji, John S.
The Paradox Association between Smoking and Blood Pressure among Half Million Chinese People
title The Paradox Association between Smoking and Blood Pressure among Half Million Chinese People
title_full The Paradox Association between Smoking and Blood Pressure among Half Million Chinese People
title_fullStr The Paradox Association between Smoking and Blood Pressure among Half Million Chinese People
title_full_unstemmed The Paradox Association between Smoking and Blood Pressure among Half Million Chinese People
title_short The Paradox Association between Smoking and Blood Pressure among Half Million Chinese People
title_sort paradox association between smoking and blood pressure among half million chinese people
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215755/
https://www.ncbi.nlm.nih.gov/pubmed/32325946
http://dx.doi.org/10.3390/ijerph17082824
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