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A Pyrimidin-Like Plant Activator Stimulates Plant Disease Resistance and Promotes the Synthesis of Primary Metabolites

Plant activators are chemicals that induce plant defense responses to various pathogens. Here, we reported a new potential plant activator, 6-(methoxymethyl)-2-[5-(trifluoromethyl)-2-pyridyl] pyrimidin-4-ol, named PPA2 (pyrimidin-type plant activator 2). Unlike the traditional commercial plant activ...

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Autores principales: Li, Jian, Long, Ting, Sun, Tie-Jun, Lu, Yun, Yin, Jian, Yang, Yu-Bing, Dai, Guang-Yi, Zhu, Xiao-Yuan, Yao, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215783/
https://www.ncbi.nlm.nih.gov/pubmed/32295118
http://dx.doi.org/10.3390/ijms21082705
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author Li, Jian
Long, Ting
Sun, Tie-Jun
Lu, Yun
Yin, Jian
Yang, Yu-Bing
Dai, Guang-Yi
Zhu, Xiao-Yuan
Yao, Nan
author_facet Li, Jian
Long, Ting
Sun, Tie-Jun
Lu, Yun
Yin, Jian
Yang, Yu-Bing
Dai, Guang-Yi
Zhu, Xiao-Yuan
Yao, Nan
author_sort Li, Jian
collection PubMed
description Plant activators are chemicals that induce plant defense responses to various pathogens. Here, we reported a new potential plant activator, 6-(methoxymethyl)-2-[5-(trifluoromethyl)-2-pyridyl] pyrimidin-4-ol, named PPA2 (pyrimidin-type plant activator 2). Unlike the traditional commercial plant activator benzothiadiazole S-methyl ester (BTH), PPA2 was fully soluble in water, and it did not inhibit plant growth or root system development in rice (Oryza sativa). PPA2 pretreatment significantly increased plant resistance against bacterial infection in both Arabidopsis and rice, in conjunction with increases in the level of jasmonoyl-isoleucine and 12-oxo-phytodienoic acid. In addition, metabolite profiling indicated that BTH significantly reduced the abundance of various primary metabolites in rice seedlings, including most amino acids, sugars, and organic acids; by contrast, PPA2 promoted their synthesis. Our results thus indicate that PPA2 enhances plant defenses against bacterial infection through the jasmonic acid pathway, and that as a water-soluble compound that can promote the synthesis of primary metabolites it has broad potential applications in agriculture.
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spelling pubmed-72157832020-05-22 A Pyrimidin-Like Plant Activator Stimulates Plant Disease Resistance and Promotes the Synthesis of Primary Metabolites Li, Jian Long, Ting Sun, Tie-Jun Lu, Yun Yin, Jian Yang, Yu-Bing Dai, Guang-Yi Zhu, Xiao-Yuan Yao, Nan Int J Mol Sci Article Plant activators are chemicals that induce plant defense responses to various pathogens. Here, we reported a new potential plant activator, 6-(methoxymethyl)-2-[5-(trifluoromethyl)-2-pyridyl] pyrimidin-4-ol, named PPA2 (pyrimidin-type plant activator 2). Unlike the traditional commercial plant activator benzothiadiazole S-methyl ester (BTH), PPA2 was fully soluble in water, and it did not inhibit plant growth or root system development in rice (Oryza sativa). PPA2 pretreatment significantly increased plant resistance against bacterial infection in both Arabidopsis and rice, in conjunction with increases in the level of jasmonoyl-isoleucine and 12-oxo-phytodienoic acid. In addition, metabolite profiling indicated that BTH significantly reduced the abundance of various primary metabolites in rice seedlings, including most amino acids, sugars, and organic acids; by contrast, PPA2 promoted their synthesis. Our results thus indicate that PPA2 enhances plant defenses against bacterial infection through the jasmonic acid pathway, and that as a water-soluble compound that can promote the synthesis of primary metabolites it has broad potential applications in agriculture. MDPI 2020-04-14 /pmc/articles/PMC7215783/ /pubmed/32295118 http://dx.doi.org/10.3390/ijms21082705 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Jian
Long, Ting
Sun, Tie-Jun
Lu, Yun
Yin, Jian
Yang, Yu-Bing
Dai, Guang-Yi
Zhu, Xiao-Yuan
Yao, Nan
A Pyrimidin-Like Plant Activator Stimulates Plant Disease Resistance and Promotes the Synthesis of Primary Metabolites
title A Pyrimidin-Like Plant Activator Stimulates Plant Disease Resistance and Promotes the Synthesis of Primary Metabolites
title_full A Pyrimidin-Like Plant Activator Stimulates Plant Disease Resistance and Promotes the Synthesis of Primary Metabolites
title_fullStr A Pyrimidin-Like Plant Activator Stimulates Plant Disease Resistance and Promotes the Synthesis of Primary Metabolites
title_full_unstemmed A Pyrimidin-Like Plant Activator Stimulates Plant Disease Resistance and Promotes the Synthesis of Primary Metabolites
title_short A Pyrimidin-Like Plant Activator Stimulates Plant Disease Resistance and Promotes the Synthesis of Primary Metabolites
title_sort pyrimidin-like plant activator stimulates plant disease resistance and promotes the synthesis of primary metabolites
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215783/
https://www.ncbi.nlm.nih.gov/pubmed/32295118
http://dx.doi.org/10.3390/ijms21082705
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