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Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin

Magnoflorine is an aporphine alkaloid present in plant species belonging to the Berberidaceae, Magnoliaceae, Menispermaceae, or Papaveraceae botanical families. The interest of magnoflorine has increased recently due to its multiplicity of pharmacological properties. The aim of this study was the an...

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Autores principales: Okon, Estera, Luszczki, Jarogniew J., Kukula-Koch, Wirginia, Halasa, Marta, Jarzab, Agata, Khurelbat, Daariimaa, Stepulak, Andrzej, Wawruszak, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215826/
https://www.ncbi.nlm.nih.gov/pubmed/32325867
http://dx.doi.org/10.3390/ijms21082848
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author Okon, Estera
Luszczki, Jarogniew J.
Kukula-Koch, Wirginia
Halasa, Marta
Jarzab, Agata
Khurelbat, Daariimaa
Stepulak, Andrzej
Wawruszak, Anna
author_facet Okon, Estera
Luszczki, Jarogniew J.
Kukula-Koch, Wirginia
Halasa, Marta
Jarzab, Agata
Khurelbat, Daariimaa
Stepulak, Andrzej
Wawruszak, Anna
author_sort Okon, Estera
collection PubMed
description Magnoflorine is an aporphine alkaloid present in plant species belonging to the Berberidaceae, Magnoliaceae, Menispermaceae, or Papaveraceae botanical families. The interest of magnoflorine has increased recently due to its multiplicity of pharmacological properties. The aim of this study was the analysis of combined anti-proliferative effect of magnoflorine and cisplatin and the assessment of drug–drug pharmacological interaction between these agents using isobolographic method in MDA-MB-468 human breast, NCIH1299 lung, TE671 rhabdomyosarcoma, or T98G glioblastoma cancer cell lines. Magnoflorine in combination with cisplatin at a fixed ratio of 1:1 augmented their anticancer action and yielded synergistic or additive pharmacological interactions by means of isobolographic method, therefore combined therapy using these two active agents can be a promising chemotherapy regimen in the treatment of some types of breast, lung, rhabdomyosarcoma, and glioblastoma cancers.
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spelling pubmed-72158262020-05-22 Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin Okon, Estera Luszczki, Jarogniew J. Kukula-Koch, Wirginia Halasa, Marta Jarzab, Agata Khurelbat, Daariimaa Stepulak, Andrzej Wawruszak, Anna Int J Mol Sci Article Magnoflorine is an aporphine alkaloid present in plant species belonging to the Berberidaceae, Magnoliaceae, Menispermaceae, or Papaveraceae botanical families. The interest of magnoflorine has increased recently due to its multiplicity of pharmacological properties. The aim of this study was the analysis of combined anti-proliferative effect of magnoflorine and cisplatin and the assessment of drug–drug pharmacological interaction between these agents using isobolographic method in MDA-MB-468 human breast, NCIH1299 lung, TE671 rhabdomyosarcoma, or T98G glioblastoma cancer cell lines. Magnoflorine in combination with cisplatin at a fixed ratio of 1:1 augmented their anticancer action and yielded synergistic or additive pharmacological interactions by means of isobolographic method, therefore combined therapy using these two active agents can be a promising chemotherapy regimen in the treatment of some types of breast, lung, rhabdomyosarcoma, and glioblastoma cancers. MDPI 2020-04-19 /pmc/articles/PMC7215826/ /pubmed/32325867 http://dx.doi.org/10.3390/ijms21082848 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Okon, Estera
Luszczki, Jarogniew J.
Kukula-Koch, Wirginia
Halasa, Marta
Jarzab, Agata
Khurelbat, Daariimaa
Stepulak, Andrzej
Wawruszak, Anna
Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin
title Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin
title_full Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin
title_fullStr Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin
title_full_unstemmed Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin
title_short Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin
title_sort synergistic or additive pharmacological interactions between magnoflorine and cisplatin in human cancer cells of different histological origin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215826/
https://www.ncbi.nlm.nih.gov/pubmed/32325867
http://dx.doi.org/10.3390/ijms21082848
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