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Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin
Magnoflorine is an aporphine alkaloid present in plant species belonging to the Berberidaceae, Magnoliaceae, Menispermaceae, or Papaveraceae botanical families. The interest of magnoflorine has increased recently due to its multiplicity of pharmacological properties. The aim of this study was the an...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215826/ https://www.ncbi.nlm.nih.gov/pubmed/32325867 http://dx.doi.org/10.3390/ijms21082848 |
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author | Okon, Estera Luszczki, Jarogniew J. Kukula-Koch, Wirginia Halasa, Marta Jarzab, Agata Khurelbat, Daariimaa Stepulak, Andrzej Wawruszak, Anna |
author_facet | Okon, Estera Luszczki, Jarogniew J. Kukula-Koch, Wirginia Halasa, Marta Jarzab, Agata Khurelbat, Daariimaa Stepulak, Andrzej Wawruszak, Anna |
author_sort | Okon, Estera |
collection | PubMed |
description | Magnoflorine is an aporphine alkaloid present in plant species belonging to the Berberidaceae, Magnoliaceae, Menispermaceae, or Papaveraceae botanical families. The interest of magnoflorine has increased recently due to its multiplicity of pharmacological properties. The aim of this study was the analysis of combined anti-proliferative effect of magnoflorine and cisplatin and the assessment of drug–drug pharmacological interaction between these agents using isobolographic method in MDA-MB-468 human breast, NCIH1299 lung, TE671 rhabdomyosarcoma, or T98G glioblastoma cancer cell lines. Magnoflorine in combination with cisplatin at a fixed ratio of 1:1 augmented their anticancer action and yielded synergistic or additive pharmacological interactions by means of isobolographic method, therefore combined therapy using these two active agents can be a promising chemotherapy regimen in the treatment of some types of breast, lung, rhabdomyosarcoma, and glioblastoma cancers. |
format | Online Article Text |
id | pubmed-7215826 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72158262020-05-22 Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin Okon, Estera Luszczki, Jarogniew J. Kukula-Koch, Wirginia Halasa, Marta Jarzab, Agata Khurelbat, Daariimaa Stepulak, Andrzej Wawruszak, Anna Int J Mol Sci Article Magnoflorine is an aporphine alkaloid present in plant species belonging to the Berberidaceae, Magnoliaceae, Menispermaceae, or Papaveraceae botanical families. The interest of magnoflorine has increased recently due to its multiplicity of pharmacological properties. The aim of this study was the analysis of combined anti-proliferative effect of magnoflorine and cisplatin and the assessment of drug–drug pharmacological interaction between these agents using isobolographic method in MDA-MB-468 human breast, NCIH1299 lung, TE671 rhabdomyosarcoma, or T98G glioblastoma cancer cell lines. Magnoflorine in combination with cisplatin at a fixed ratio of 1:1 augmented their anticancer action and yielded synergistic or additive pharmacological interactions by means of isobolographic method, therefore combined therapy using these two active agents can be a promising chemotherapy regimen in the treatment of some types of breast, lung, rhabdomyosarcoma, and glioblastoma cancers. MDPI 2020-04-19 /pmc/articles/PMC7215826/ /pubmed/32325867 http://dx.doi.org/10.3390/ijms21082848 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Okon, Estera Luszczki, Jarogniew J. Kukula-Koch, Wirginia Halasa, Marta Jarzab, Agata Khurelbat, Daariimaa Stepulak, Andrzej Wawruszak, Anna Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin |
title | Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin |
title_full | Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin |
title_fullStr | Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin |
title_full_unstemmed | Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin |
title_short | Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin |
title_sort | synergistic or additive pharmacological interactions between magnoflorine and cisplatin in human cancer cells of different histological origin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215826/ https://www.ncbi.nlm.nih.gov/pubmed/32325867 http://dx.doi.org/10.3390/ijms21082848 |
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