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Drug Thrombus Resulting in Superior Vena Cava Syndrome: A Case Report
INTRODUCTION: Superior vena cava syndrome is one of the more serious complications of central venous catheter insertion. Drug interactions of administered drugs used in association with these catheters can lead to formation of precipitations and consequently thrombus formation. These interactions ca...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sciendo
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216030/ https://www.ncbi.nlm.nih.gov/pubmed/32426518 http://dx.doi.org/10.2478/jccm-2020-0015 |
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author | Vanstraelen, Stijn Vandenbrande, Jeroen Yilmaz, Alaaddin |
author_facet | Vanstraelen, Stijn Vandenbrande, Jeroen Yilmaz, Alaaddin |
author_sort | Vanstraelen, Stijn |
collection | PubMed |
description | INTRODUCTION: Superior vena cava syndrome is one of the more serious complications of central venous catheter insertion. Drug interactions of administered drugs used in association with these catheters can lead to formation of precipitations and consequently thrombus formation. These interactions can be either anion-cation or acid-base based and more commonly present in clinical practice than expected. CASE PRESENTATION: The case of a 31-year old female who was admitted to an intensive care unit with an intracranial haemorrhage, is presented. Occlusion of the superior vena cava was caused by a drug-induced thrombus, formed by the precipitation and clotting of total parenteral nutrition and intravenous drugs. Given the nature of the thrombus and a recent intracranial haemorrhage, the patient was treated with a central thrombectomy supported by a heparin-free extracorporeal membrane oxygenation. CONCLUSION: Knowledge of drug interactions is crucial in order to heighten awareness for the dangers of concomitant drug administration, especially in combination with total parenteral nutrition in critically ill patients. |
format | Online Article Text |
id | pubmed-7216030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Sciendo |
record_format | MEDLINE/PubMed |
spelling | pubmed-72160302020-05-18 Drug Thrombus Resulting in Superior Vena Cava Syndrome: A Case Report Vanstraelen, Stijn Vandenbrande, Jeroen Yilmaz, Alaaddin J Crit Care Med (Targu Mures) Case Report INTRODUCTION: Superior vena cava syndrome is one of the more serious complications of central venous catheter insertion. Drug interactions of administered drugs used in association with these catheters can lead to formation of precipitations and consequently thrombus formation. These interactions can be either anion-cation or acid-base based and more commonly present in clinical practice than expected. CASE PRESENTATION: The case of a 31-year old female who was admitted to an intensive care unit with an intracranial haemorrhage, is presented. Occlusion of the superior vena cava was caused by a drug-induced thrombus, formed by the precipitation and clotting of total parenteral nutrition and intravenous drugs. Given the nature of the thrombus and a recent intracranial haemorrhage, the patient was treated with a central thrombectomy supported by a heparin-free extracorporeal membrane oxygenation. CONCLUSION: Knowledge of drug interactions is crucial in order to heighten awareness for the dangers of concomitant drug administration, especially in combination with total parenteral nutrition in critically ill patients. Sciendo 2020-05-06 /pmc/articles/PMC7216030/ /pubmed/32426518 http://dx.doi.org/10.2478/jccm-2020-0015 Text en © 2020 Stijn Vanstraelen, Jeroen Vandenbrande, Alaaddin Yilmaz, published by Sciendo http://creativecommons.org/licenses/by-nc-nd/4.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. |
spellingShingle | Case Report Vanstraelen, Stijn Vandenbrande, Jeroen Yilmaz, Alaaddin Drug Thrombus Resulting in Superior Vena Cava Syndrome: A Case Report |
title | Drug Thrombus Resulting in Superior Vena Cava Syndrome: A Case Report |
title_full | Drug Thrombus Resulting in Superior Vena Cava Syndrome: A Case Report |
title_fullStr | Drug Thrombus Resulting in Superior Vena Cava Syndrome: A Case Report |
title_full_unstemmed | Drug Thrombus Resulting in Superior Vena Cava Syndrome: A Case Report |
title_short | Drug Thrombus Resulting in Superior Vena Cava Syndrome: A Case Report |
title_sort | drug thrombus resulting in superior vena cava syndrome: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216030/ https://www.ncbi.nlm.nih.gov/pubmed/32426518 http://dx.doi.org/10.2478/jccm-2020-0015 |
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