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Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials
Sore, infected wounds are a major clinical issue, and there is thus an urgent need for novel biomaterials as multifunctional constituents for dressings. A set of biocomposites was prepared by solvent casting using different concentrations of carboxymethylcellulose (CMC) and exfoliated graphene oxide...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216044/ https://www.ncbi.nlm.nih.gov/pubmed/32340390 http://dx.doi.org/10.3390/ma13081980 |
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author | Saladino, Maria Luisa Markowska, Marta Carmone, Clara Cancemi, Patrizia Alduina, Rosa Presentato, Alessandro Scaffaro, Roberto Biały, Dariusz Hasiak, Mariusz Hreniak, Dariusz Wawrzyńska, Magdalena |
author_facet | Saladino, Maria Luisa Markowska, Marta Carmone, Clara Cancemi, Patrizia Alduina, Rosa Presentato, Alessandro Scaffaro, Roberto Biały, Dariusz Hasiak, Mariusz Hreniak, Dariusz Wawrzyńska, Magdalena |
author_sort | Saladino, Maria Luisa |
collection | PubMed |
description | Sore, infected wounds are a major clinical issue, and there is thus an urgent need for novel biomaterials as multifunctional constituents for dressings. A set of biocomposites was prepared by solvent casting using different concentrations of carboxymethylcellulose (CMC) and exfoliated graphene oxide (Exf-GO) as a filler. Exf-GO was first obtained by the strong oxidation and exfoliation of graphite. The structural, morphological and mechanical properties of the composites (CMCx/Exf-GO) were evaluated, and the obtained composites were homogenous, transparent and brownish in color. The results confirmed that Exf-GO may be homogeneously dispersed in CMC. It was found that the composite has an inhibitory activity against the Gram-positive Staphylococcus aureus, but not against Gram-negative Pseudomonas aeruginosa. At the same time, it does not exhibit any cytotoxic effect on normal fibroblasts. |
format | Online Article Text |
id | pubmed-7216044 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72160442020-05-22 Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials Saladino, Maria Luisa Markowska, Marta Carmone, Clara Cancemi, Patrizia Alduina, Rosa Presentato, Alessandro Scaffaro, Roberto Biały, Dariusz Hasiak, Mariusz Hreniak, Dariusz Wawrzyńska, Magdalena Materials (Basel) Article Sore, infected wounds are a major clinical issue, and there is thus an urgent need for novel biomaterials as multifunctional constituents for dressings. A set of biocomposites was prepared by solvent casting using different concentrations of carboxymethylcellulose (CMC) and exfoliated graphene oxide (Exf-GO) as a filler. Exf-GO was first obtained by the strong oxidation and exfoliation of graphite. The structural, morphological and mechanical properties of the composites (CMCx/Exf-GO) were evaluated, and the obtained composites were homogenous, transparent and brownish in color. The results confirmed that Exf-GO may be homogeneously dispersed in CMC. It was found that the composite has an inhibitory activity against the Gram-positive Staphylococcus aureus, but not against Gram-negative Pseudomonas aeruginosa. At the same time, it does not exhibit any cytotoxic effect on normal fibroblasts. MDPI 2020-04-23 /pmc/articles/PMC7216044/ /pubmed/32340390 http://dx.doi.org/10.3390/ma13081980 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Saladino, Maria Luisa Markowska, Marta Carmone, Clara Cancemi, Patrizia Alduina, Rosa Presentato, Alessandro Scaffaro, Roberto Biały, Dariusz Hasiak, Mariusz Hreniak, Dariusz Wawrzyńska, Magdalena Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials |
title | Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials |
title_full | Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials |
title_fullStr | Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials |
title_full_unstemmed | Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials |
title_short | Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials |
title_sort | graphene oxide carboxymethylcellulose nanocomposite for dressing materials |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216044/ https://www.ncbi.nlm.nih.gov/pubmed/32340390 http://dx.doi.org/10.3390/ma13081980 |
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