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Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials

Sore, infected wounds are a major clinical issue, and there is thus an urgent need for novel biomaterials as multifunctional constituents for dressings. A set of biocomposites was prepared by solvent casting using different concentrations of carboxymethylcellulose (CMC) and exfoliated graphene oxide...

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Autores principales: Saladino, Maria Luisa, Markowska, Marta, Carmone, Clara, Cancemi, Patrizia, Alduina, Rosa, Presentato, Alessandro, Scaffaro, Roberto, Biały, Dariusz, Hasiak, Mariusz, Hreniak, Dariusz, Wawrzyńska, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216044/
https://www.ncbi.nlm.nih.gov/pubmed/32340390
http://dx.doi.org/10.3390/ma13081980
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author Saladino, Maria Luisa
Markowska, Marta
Carmone, Clara
Cancemi, Patrizia
Alduina, Rosa
Presentato, Alessandro
Scaffaro, Roberto
Biały, Dariusz
Hasiak, Mariusz
Hreniak, Dariusz
Wawrzyńska, Magdalena
author_facet Saladino, Maria Luisa
Markowska, Marta
Carmone, Clara
Cancemi, Patrizia
Alduina, Rosa
Presentato, Alessandro
Scaffaro, Roberto
Biały, Dariusz
Hasiak, Mariusz
Hreniak, Dariusz
Wawrzyńska, Magdalena
author_sort Saladino, Maria Luisa
collection PubMed
description Sore, infected wounds are a major clinical issue, and there is thus an urgent need for novel biomaterials as multifunctional constituents for dressings. A set of biocomposites was prepared by solvent casting using different concentrations of carboxymethylcellulose (CMC) and exfoliated graphene oxide (Exf-GO) as a filler. Exf-GO was first obtained by the strong oxidation and exfoliation of graphite. The structural, morphological and mechanical properties of the composites (CMCx/Exf-GO) were evaluated, and the obtained composites were homogenous, transparent and brownish in color. The results confirmed that Exf-GO may be homogeneously dispersed in CMC. It was found that the composite has an inhibitory activity against the Gram-positive Staphylococcus aureus, but not against Gram-negative Pseudomonas aeruginosa. At the same time, it does not exhibit any cytotoxic effect on normal fibroblasts.
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spelling pubmed-72160442020-05-22 Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials Saladino, Maria Luisa Markowska, Marta Carmone, Clara Cancemi, Patrizia Alduina, Rosa Presentato, Alessandro Scaffaro, Roberto Biały, Dariusz Hasiak, Mariusz Hreniak, Dariusz Wawrzyńska, Magdalena Materials (Basel) Article Sore, infected wounds are a major clinical issue, and there is thus an urgent need for novel biomaterials as multifunctional constituents for dressings. A set of biocomposites was prepared by solvent casting using different concentrations of carboxymethylcellulose (CMC) and exfoliated graphene oxide (Exf-GO) as a filler. Exf-GO was first obtained by the strong oxidation and exfoliation of graphite. The structural, morphological and mechanical properties of the composites (CMCx/Exf-GO) were evaluated, and the obtained composites were homogenous, transparent and brownish in color. The results confirmed that Exf-GO may be homogeneously dispersed in CMC. It was found that the composite has an inhibitory activity against the Gram-positive Staphylococcus aureus, but not against Gram-negative Pseudomonas aeruginosa. At the same time, it does not exhibit any cytotoxic effect on normal fibroblasts. MDPI 2020-04-23 /pmc/articles/PMC7216044/ /pubmed/32340390 http://dx.doi.org/10.3390/ma13081980 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Saladino, Maria Luisa
Markowska, Marta
Carmone, Clara
Cancemi, Patrizia
Alduina, Rosa
Presentato, Alessandro
Scaffaro, Roberto
Biały, Dariusz
Hasiak, Mariusz
Hreniak, Dariusz
Wawrzyńska, Magdalena
Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials
title Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials
title_full Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials
title_fullStr Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials
title_full_unstemmed Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials
title_short Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials
title_sort graphene oxide carboxymethylcellulose nanocomposite for dressing materials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216044/
https://www.ncbi.nlm.nih.gov/pubmed/32340390
http://dx.doi.org/10.3390/ma13081980
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