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A Metabolically Healthy Profile Is a Transient Stage When Exercise and Diet Are Not Supervised: Long-Term Effects in the EXERDIET-HTA Study

Metabolically unhealthy obesity (MUO) is a regular state in people with primary hypertension (HTN), obesity, and who are physically inactive. To achieve and maintain a metabolically healthy overweight/obese (MHO) state should be a main treatment goal. The aims of the study were (1) to determine diff...

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Autores principales: Corres, Pablo, Fryer, Simon M., Aguirre-Betolaza, Aitor Martínez, Gorostegi-Anduaga, Ilargi, Arratibel-Imaz, Iñaki, Pérez-Asenjo, Javier, Francisco-Terreros, Silvia, Saracho, Ramón, Maldonado-Martín, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216152/
https://www.ncbi.nlm.nih.gov/pubmed/32326133
http://dx.doi.org/10.3390/ijerph17082830
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author Corres, Pablo
Fryer, Simon M.
Aguirre-Betolaza, Aitor Martínez
Gorostegi-Anduaga, Ilargi
Arratibel-Imaz, Iñaki
Pérez-Asenjo, Javier
Francisco-Terreros, Silvia
Saracho, Ramón
Maldonado-Martín, Sara
author_facet Corres, Pablo
Fryer, Simon M.
Aguirre-Betolaza, Aitor Martínez
Gorostegi-Anduaga, Ilargi
Arratibel-Imaz, Iñaki
Pérez-Asenjo, Javier
Francisco-Terreros, Silvia
Saracho, Ramón
Maldonado-Martín, Sara
author_sort Corres, Pablo
collection PubMed
description Metabolically unhealthy obesity (MUO) is a regular state in people with primary hypertension (HTN), obesity, and who are physically inactive. To achieve and maintain a metabolically healthy overweight/obese (MHO) state should be a main treatment goal. The aims of the study were (1) to determine differences in metabolic profiles of overweight/obese, physically inactive individuals with HTN following a 16-week (POST) supervised aerobic exercise training (SupExT) intervention with an attentional control (AC) group, and (2) to determine whether the changes observed were maintained following six months (6 M) of unsupervised time. Participants (n = 219) were randomly assigned into AC or SupExT groups. All participants underwent a hypocaloric diet. At POST, all participants received diet and physical activity advice for the following 6 M, with no supervision. All measurements were assessed pre-intervention (PRE), POST, and after 6 M. From PRE to POST, MUO participants became MHO with improved (p < 0.05) total cholesterol (TC, ∆ = −12.1 mg/dL), alanine aminotransferase (∆ = −8.3 U/L), glucose (∆ = −5.5 mg/dL), C-reactive protein (∆ = −1.4 mg/dL), systolic blood pressure (SBP), and cardiorespiratory fitness (CRF) compared to unhealthy optimal cut-off values. However, after 6 M, TC, glucose, and SBP returned to unhealthy values (p < 0.05). In a non-physically active population with obesity and HTN, a 16-week SupExT and diet intervention significantly improves cardiometabolic profile from MUO to MHO. However, after 6 M of no supervision, participants returned to MUO. The findings of this study highlight the need for regular, systematic, and supervised diet and exercise programs to avoid subsequent declines in cardiometabolic health.
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spelling pubmed-72161522020-05-22 A Metabolically Healthy Profile Is a Transient Stage When Exercise and Diet Are Not Supervised: Long-Term Effects in the EXERDIET-HTA Study Corres, Pablo Fryer, Simon M. Aguirre-Betolaza, Aitor Martínez Gorostegi-Anduaga, Ilargi Arratibel-Imaz, Iñaki Pérez-Asenjo, Javier Francisco-Terreros, Silvia Saracho, Ramón Maldonado-Martín, Sara Int J Environ Res Public Health Article Metabolically unhealthy obesity (MUO) is a regular state in people with primary hypertension (HTN), obesity, and who are physically inactive. To achieve and maintain a metabolically healthy overweight/obese (MHO) state should be a main treatment goal. The aims of the study were (1) to determine differences in metabolic profiles of overweight/obese, physically inactive individuals with HTN following a 16-week (POST) supervised aerobic exercise training (SupExT) intervention with an attentional control (AC) group, and (2) to determine whether the changes observed were maintained following six months (6 M) of unsupervised time. Participants (n = 219) were randomly assigned into AC or SupExT groups. All participants underwent a hypocaloric diet. At POST, all participants received diet and physical activity advice for the following 6 M, with no supervision. All measurements were assessed pre-intervention (PRE), POST, and after 6 M. From PRE to POST, MUO participants became MHO with improved (p < 0.05) total cholesterol (TC, ∆ = −12.1 mg/dL), alanine aminotransferase (∆ = −8.3 U/L), glucose (∆ = −5.5 mg/dL), C-reactive protein (∆ = −1.4 mg/dL), systolic blood pressure (SBP), and cardiorespiratory fitness (CRF) compared to unhealthy optimal cut-off values. However, after 6 M, TC, glucose, and SBP returned to unhealthy values (p < 0.05). In a non-physically active population with obesity and HTN, a 16-week SupExT and diet intervention significantly improves cardiometabolic profile from MUO to MHO. However, after 6 M of no supervision, participants returned to MUO. The findings of this study highlight the need for regular, systematic, and supervised diet and exercise programs to avoid subsequent declines in cardiometabolic health. MDPI 2020-04-20 2020-04 /pmc/articles/PMC7216152/ /pubmed/32326133 http://dx.doi.org/10.3390/ijerph17082830 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Corres, Pablo
Fryer, Simon M.
Aguirre-Betolaza, Aitor Martínez
Gorostegi-Anduaga, Ilargi
Arratibel-Imaz, Iñaki
Pérez-Asenjo, Javier
Francisco-Terreros, Silvia
Saracho, Ramón
Maldonado-Martín, Sara
A Metabolically Healthy Profile Is a Transient Stage When Exercise and Diet Are Not Supervised: Long-Term Effects in the EXERDIET-HTA Study
title A Metabolically Healthy Profile Is a Transient Stage When Exercise and Diet Are Not Supervised: Long-Term Effects in the EXERDIET-HTA Study
title_full A Metabolically Healthy Profile Is a Transient Stage When Exercise and Diet Are Not Supervised: Long-Term Effects in the EXERDIET-HTA Study
title_fullStr A Metabolically Healthy Profile Is a Transient Stage When Exercise and Diet Are Not Supervised: Long-Term Effects in the EXERDIET-HTA Study
title_full_unstemmed A Metabolically Healthy Profile Is a Transient Stage When Exercise and Diet Are Not Supervised: Long-Term Effects in the EXERDIET-HTA Study
title_short A Metabolically Healthy Profile Is a Transient Stage When Exercise and Diet Are Not Supervised: Long-Term Effects in the EXERDIET-HTA Study
title_sort metabolically healthy profile is a transient stage when exercise and diet are not supervised: long-term effects in the exerdiet-hta study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216152/
https://www.ncbi.nlm.nih.gov/pubmed/32326133
http://dx.doi.org/10.3390/ijerph17082830
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