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Growth Modulatory Role of Zinc in Prostate Cancer and Application to Cancer Therapeutics

Zinc is a group IIB heavy metal. It is an important regulator of major cell signaling pathways in most mammalian cells, functions as an antioxidant and plays a role in maintaining genomic stability. Zinc deficiency leads to severe diseases in the brain, pancreas, liver, kidneys and reproductive orga...

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Autores principales: To, Phuong Kim, Do, Manh Hung, Cho, Jin-Hyoung, Jung, Chaeyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216164/
https://www.ncbi.nlm.nih.gov/pubmed/32340289
http://dx.doi.org/10.3390/ijms21082991
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author To, Phuong Kim
Do, Manh Hung
Cho, Jin-Hyoung
Jung, Chaeyong
author_facet To, Phuong Kim
Do, Manh Hung
Cho, Jin-Hyoung
Jung, Chaeyong
author_sort To, Phuong Kim
collection PubMed
description Zinc is a group IIB heavy metal. It is an important regulator of major cell signaling pathways in most mammalian cells, functions as an antioxidant and plays a role in maintaining genomic stability. Zinc deficiency leads to severe diseases in the brain, pancreas, liver, kidneys and reproductive organs. Zinc loss occurs during tumor development in a variety of cancers. The prostate normally contains abundant intracellular zinc and zinc loss is a hallmark of the development of prostate cancer development. The underlying mechanism of this loss is not clearly understood. The knowledge that excess zinc prevents the growth of prostate cancers suggests that zinc-mediated therapeutics could be an effective approach for cancer prevention and treatment, although challenges remain. This review summarizes the specific roles of zinc in several cancer types focusing on prostate cancer. The relationship between prostate cancer and the dysregulation of zinc homeostasis is examined in detail in an effort to understand the role of zinc in prostate cancer.
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spelling pubmed-72161642020-05-22 Growth Modulatory Role of Zinc in Prostate Cancer and Application to Cancer Therapeutics To, Phuong Kim Do, Manh Hung Cho, Jin-Hyoung Jung, Chaeyong Int J Mol Sci Review Zinc is a group IIB heavy metal. It is an important regulator of major cell signaling pathways in most mammalian cells, functions as an antioxidant and plays a role in maintaining genomic stability. Zinc deficiency leads to severe diseases in the brain, pancreas, liver, kidneys and reproductive organs. Zinc loss occurs during tumor development in a variety of cancers. The prostate normally contains abundant intracellular zinc and zinc loss is a hallmark of the development of prostate cancer development. The underlying mechanism of this loss is not clearly understood. The knowledge that excess zinc prevents the growth of prostate cancers suggests that zinc-mediated therapeutics could be an effective approach for cancer prevention and treatment, although challenges remain. This review summarizes the specific roles of zinc in several cancer types focusing on prostate cancer. The relationship between prostate cancer and the dysregulation of zinc homeostasis is examined in detail in an effort to understand the role of zinc in prostate cancer. MDPI 2020-04-23 /pmc/articles/PMC7216164/ /pubmed/32340289 http://dx.doi.org/10.3390/ijms21082991 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
To, Phuong Kim
Do, Manh Hung
Cho, Jin-Hyoung
Jung, Chaeyong
Growth Modulatory Role of Zinc in Prostate Cancer and Application to Cancer Therapeutics
title Growth Modulatory Role of Zinc in Prostate Cancer and Application to Cancer Therapeutics
title_full Growth Modulatory Role of Zinc in Prostate Cancer and Application to Cancer Therapeutics
title_fullStr Growth Modulatory Role of Zinc in Prostate Cancer and Application to Cancer Therapeutics
title_full_unstemmed Growth Modulatory Role of Zinc in Prostate Cancer and Application to Cancer Therapeutics
title_short Growth Modulatory Role of Zinc in Prostate Cancer and Application to Cancer Therapeutics
title_sort growth modulatory role of zinc in prostate cancer and application to cancer therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216164/
https://www.ncbi.nlm.nih.gov/pubmed/32340289
http://dx.doi.org/10.3390/ijms21082991
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