Resveratrol in Cancer Patients: From Bench to Bedside

Resveratrol (3,5,4′-trihydroxystilbene) is a natural phytoalexin that accumulates in several vegetables and fruits like nuts, grapes, apples, red fruits, black olives, capers, red rice as well as red wines. Being both an extremely reactive molecule and capable to interact with cytoplasmic and nuclea...

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Detalles Bibliográficos
Autores principales: Berretta, Massimiliano, Bignucolo, Alessia, Di Francia, Raffaele, Comello, Francesco, Facchini, Gaetano, Ceccarelli, Manuela, Iaffaioli, Rosario Vincenzo, Quagliariello, Vincenzo, Maurea, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216168/
https://www.ncbi.nlm.nih.gov/pubmed/32331450
http://dx.doi.org/10.3390/ijms21082945
Descripción
Sumario:Resveratrol (3,5,4′-trihydroxystilbene) is a natural phytoalexin that accumulates in several vegetables and fruits like nuts, grapes, apples, red fruits, black olives, capers, red rice as well as red wines. Being both an extremely reactive molecule and capable to interact with cytoplasmic and nuclear proteins in human cells, resveratrol has been studied over the years as complementary and alternative medicine (CAM) for the therapy of cancer, metabolic and cardiovascular diseases like myocardial ischemia, myocarditis, cardiac hypertrophy and heart failure. This review will describe the main biological targets, cardiovascular outcomes, physico-chemical and pharmacokinetic properties of resveratrol in preclinical and clinical models implementing its potential use in cancer patients.

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