Resveratrol in Cancer Patients: From Bench to Bedside

Resveratrol (3,5,4′-trihydroxystilbene) is a natural phytoalexin that accumulates in several vegetables and fruits like nuts, grapes, apples, red fruits, black olives, capers, red rice as well as red wines. Being both an extremely reactive molecule and capable to interact with cytoplasmic and nuclea...

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Autores principales: Berretta, Massimiliano, Bignucolo, Alessia, Di Francia, Raffaele, Comello, Francesco, Facchini, Gaetano, Ceccarelli, Manuela, Iaffaioli, Rosario Vincenzo, Quagliariello, Vincenzo, Maurea, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216168/
https://www.ncbi.nlm.nih.gov/pubmed/32331450
http://dx.doi.org/10.3390/ijms21082945
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author Berretta, Massimiliano
Bignucolo, Alessia
Di Francia, Raffaele
Comello, Francesco
Facchini, Gaetano
Ceccarelli, Manuela
Iaffaioli, Rosario Vincenzo
Quagliariello, Vincenzo
Maurea, Nicola
author_facet Berretta, Massimiliano
Bignucolo, Alessia
Di Francia, Raffaele
Comello, Francesco
Facchini, Gaetano
Ceccarelli, Manuela
Iaffaioli, Rosario Vincenzo
Quagliariello, Vincenzo
Maurea, Nicola
author_sort Berretta, Massimiliano
collection PubMed
description Resveratrol (3,5,4′-trihydroxystilbene) is a natural phytoalexin that accumulates in several vegetables and fruits like nuts, grapes, apples, red fruits, black olives, capers, red rice as well as red wines. Being both an extremely reactive molecule and capable to interact with cytoplasmic and nuclear proteins in human cells, resveratrol has been studied over the years as complementary and alternative medicine (CAM) for the therapy of cancer, metabolic and cardiovascular diseases like myocardial ischemia, myocarditis, cardiac hypertrophy and heart failure. This review will describe the main biological targets, cardiovascular outcomes, physico-chemical and pharmacokinetic properties of resveratrol in preclinical and clinical models implementing its potential use in cancer patients.
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spelling pubmed-72161682020-05-22 Resveratrol in Cancer Patients: From Bench to Bedside Berretta, Massimiliano Bignucolo, Alessia Di Francia, Raffaele Comello, Francesco Facchini, Gaetano Ceccarelli, Manuela Iaffaioli, Rosario Vincenzo Quagliariello, Vincenzo Maurea, Nicola Int J Mol Sci Review Resveratrol (3,5,4′-trihydroxystilbene) is a natural phytoalexin that accumulates in several vegetables and fruits like nuts, grapes, apples, red fruits, black olives, capers, red rice as well as red wines. Being both an extremely reactive molecule and capable to interact with cytoplasmic and nuclear proteins in human cells, resveratrol has been studied over the years as complementary and alternative medicine (CAM) for the therapy of cancer, metabolic and cardiovascular diseases like myocardial ischemia, myocarditis, cardiac hypertrophy and heart failure. This review will describe the main biological targets, cardiovascular outcomes, physico-chemical and pharmacokinetic properties of resveratrol in preclinical and clinical models implementing its potential use in cancer patients. MDPI 2020-04-22 /pmc/articles/PMC7216168/ /pubmed/32331450 http://dx.doi.org/10.3390/ijms21082945 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Berretta, Massimiliano
Bignucolo, Alessia
Di Francia, Raffaele
Comello, Francesco
Facchini, Gaetano
Ceccarelli, Manuela
Iaffaioli, Rosario Vincenzo
Quagliariello, Vincenzo
Maurea, Nicola
Resveratrol in Cancer Patients: From Bench to Bedside
title Resveratrol in Cancer Patients: From Bench to Bedside
title_full Resveratrol in Cancer Patients: From Bench to Bedside
title_fullStr Resveratrol in Cancer Patients: From Bench to Bedside
title_full_unstemmed Resveratrol in Cancer Patients: From Bench to Bedside
title_short Resveratrol in Cancer Patients: From Bench to Bedside
title_sort resveratrol in cancer patients: from bench to bedside
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216168/
https://www.ncbi.nlm.nih.gov/pubmed/32331450
http://dx.doi.org/10.3390/ijms21082945
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