Cargando…

Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer

In this work, we sought to investigate the effects of a thiosulfinate-enriched garlic extract, co-administered with 5-fluorouracil (5-FU) or oxaliplatin chemotherapy, on the viability of colon cancer cells (Caco-2 and HT-29). We also addressed the economic feasibility of a new combined treatment of...

Descripción completa

Detalles Bibliográficos
Autores principales: Perez-Ortiz, Jose Manuel, Galan-Moya, Eva Maria, de la Cruz-Morcillo, Miguel Angel, Rodriguez, Juan Francisco, Gracia, Ignacio, Garcia, Maria Teresa, Redondo-Calvo, Francisco Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216288/
https://www.ncbi.nlm.nih.gov/pubmed/32316312
http://dx.doi.org/10.3390/ijms21082766
_version_ 1783532384500580352
author Perez-Ortiz, Jose Manuel
Galan-Moya, Eva Maria
de la Cruz-Morcillo, Miguel Angel
Rodriguez, Juan Francisco
Gracia, Ignacio
Garcia, Maria Teresa
Redondo-Calvo, Francisco Javier
author_facet Perez-Ortiz, Jose Manuel
Galan-Moya, Eva Maria
de la Cruz-Morcillo, Miguel Angel
Rodriguez, Juan Francisco
Gracia, Ignacio
Garcia, Maria Teresa
Redondo-Calvo, Francisco Javier
author_sort Perez-Ortiz, Jose Manuel
collection PubMed
description In this work, we sought to investigate the effects of a thiosulfinate-enriched garlic extract, co-administered with 5-fluorouracil (5-FU) or oxaliplatin chemotherapy, on the viability of colon cancer cells (Caco-2 and HT-29). We also addressed the economic feasibility of a new combined treatment of this thiosulfinate-enriched garlic extract, with oxaliplatin that could reduce the dosage and costs of a monotherapy. The thiosulfinate-enriched garlic extract not only enhanced the impact of 5-FU and oxaliplatin (500 µM) in decreasing Caco-2 and HT-29 viability, but also showed a higher effect than standard 5-FU and oxaliplatin chemotherapy as anti-cancer agents. These results provided evidences for the combination of lyophilized garlic extract and 5-FU or oxaliplatin as a novel chemotherapy regimen in colon cancer cells that may also reduce the clinical therapy costs.
format Online
Article
Text
id pubmed-7216288
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72162882020-05-22 Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer Perez-Ortiz, Jose Manuel Galan-Moya, Eva Maria de la Cruz-Morcillo, Miguel Angel Rodriguez, Juan Francisco Gracia, Ignacio Garcia, Maria Teresa Redondo-Calvo, Francisco Javier Int J Mol Sci Article In this work, we sought to investigate the effects of a thiosulfinate-enriched garlic extract, co-administered with 5-fluorouracil (5-FU) or oxaliplatin chemotherapy, on the viability of colon cancer cells (Caco-2 and HT-29). We also addressed the economic feasibility of a new combined treatment of this thiosulfinate-enriched garlic extract, with oxaliplatin that could reduce the dosage and costs of a monotherapy. The thiosulfinate-enriched garlic extract not only enhanced the impact of 5-FU and oxaliplatin (500 µM) in decreasing Caco-2 and HT-29 viability, but also showed a higher effect than standard 5-FU and oxaliplatin chemotherapy as anti-cancer agents. These results provided evidences for the combination of lyophilized garlic extract and 5-FU or oxaliplatin as a novel chemotherapy regimen in colon cancer cells that may also reduce the clinical therapy costs. MDPI 2020-04-16 /pmc/articles/PMC7216288/ /pubmed/32316312 http://dx.doi.org/10.3390/ijms21082766 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Perez-Ortiz, Jose Manuel
Galan-Moya, Eva Maria
de la Cruz-Morcillo, Miguel Angel
Rodriguez, Juan Francisco
Gracia, Ignacio
Garcia, Maria Teresa
Redondo-Calvo, Francisco Javier
Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer
title Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer
title_full Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer
title_fullStr Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer
title_full_unstemmed Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer
title_short Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer
title_sort cost effective use of a thiosulfinate-enriched allium sativum extract in combination with chemotherapy in colon cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216288/
https://www.ncbi.nlm.nih.gov/pubmed/32316312
http://dx.doi.org/10.3390/ijms21082766
work_keys_str_mv AT perezortizjosemanuel costeffectiveuseofathiosulfinateenrichedalliumsativumextractincombinationwithchemotherapyincoloncancer
AT galanmoyaevamaria costeffectiveuseofathiosulfinateenrichedalliumsativumextractincombinationwithchemotherapyincoloncancer
AT delacruzmorcillomiguelangel costeffectiveuseofathiosulfinateenrichedalliumsativumextractincombinationwithchemotherapyincoloncancer
AT rodriguezjuanfrancisco costeffectiveuseofathiosulfinateenrichedalliumsativumextractincombinationwithchemotherapyincoloncancer
AT graciaignacio costeffectiveuseofathiosulfinateenrichedalliumsativumextractincombinationwithchemotherapyincoloncancer
AT garciamariateresa costeffectiveuseofathiosulfinateenrichedalliumsativumextractincombinationwithchemotherapyincoloncancer
AT redondocalvofranciscojavier costeffectiveuseofathiosulfinateenrichedalliumsativumextractincombinationwithchemotherapyincoloncancer