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Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer
In this work, we sought to investigate the effects of a thiosulfinate-enriched garlic extract, co-administered with 5-fluorouracil (5-FU) or oxaliplatin chemotherapy, on the viability of colon cancer cells (Caco-2 and HT-29). We also addressed the economic feasibility of a new combined treatment of...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216288/ https://www.ncbi.nlm.nih.gov/pubmed/32316312 http://dx.doi.org/10.3390/ijms21082766 |
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author | Perez-Ortiz, Jose Manuel Galan-Moya, Eva Maria de la Cruz-Morcillo, Miguel Angel Rodriguez, Juan Francisco Gracia, Ignacio Garcia, Maria Teresa Redondo-Calvo, Francisco Javier |
author_facet | Perez-Ortiz, Jose Manuel Galan-Moya, Eva Maria de la Cruz-Morcillo, Miguel Angel Rodriguez, Juan Francisco Gracia, Ignacio Garcia, Maria Teresa Redondo-Calvo, Francisco Javier |
author_sort | Perez-Ortiz, Jose Manuel |
collection | PubMed |
description | In this work, we sought to investigate the effects of a thiosulfinate-enriched garlic extract, co-administered with 5-fluorouracil (5-FU) or oxaliplatin chemotherapy, on the viability of colon cancer cells (Caco-2 and HT-29). We also addressed the economic feasibility of a new combined treatment of this thiosulfinate-enriched garlic extract, with oxaliplatin that could reduce the dosage and costs of a monotherapy. The thiosulfinate-enriched garlic extract not only enhanced the impact of 5-FU and oxaliplatin (500 µM) in decreasing Caco-2 and HT-29 viability, but also showed a higher effect than standard 5-FU and oxaliplatin chemotherapy as anti-cancer agents. These results provided evidences for the combination of lyophilized garlic extract and 5-FU or oxaliplatin as a novel chemotherapy regimen in colon cancer cells that may also reduce the clinical therapy costs. |
format | Online Article Text |
id | pubmed-7216288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72162882020-05-22 Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer Perez-Ortiz, Jose Manuel Galan-Moya, Eva Maria de la Cruz-Morcillo, Miguel Angel Rodriguez, Juan Francisco Gracia, Ignacio Garcia, Maria Teresa Redondo-Calvo, Francisco Javier Int J Mol Sci Article In this work, we sought to investigate the effects of a thiosulfinate-enriched garlic extract, co-administered with 5-fluorouracil (5-FU) or oxaliplatin chemotherapy, on the viability of colon cancer cells (Caco-2 and HT-29). We also addressed the economic feasibility of a new combined treatment of this thiosulfinate-enriched garlic extract, with oxaliplatin that could reduce the dosage and costs of a monotherapy. The thiosulfinate-enriched garlic extract not only enhanced the impact of 5-FU and oxaliplatin (500 µM) in decreasing Caco-2 and HT-29 viability, but also showed a higher effect than standard 5-FU and oxaliplatin chemotherapy as anti-cancer agents. These results provided evidences for the combination of lyophilized garlic extract and 5-FU or oxaliplatin as a novel chemotherapy regimen in colon cancer cells that may also reduce the clinical therapy costs. MDPI 2020-04-16 /pmc/articles/PMC7216288/ /pubmed/32316312 http://dx.doi.org/10.3390/ijms21082766 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Perez-Ortiz, Jose Manuel Galan-Moya, Eva Maria de la Cruz-Morcillo, Miguel Angel Rodriguez, Juan Francisco Gracia, Ignacio Garcia, Maria Teresa Redondo-Calvo, Francisco Javier Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer |
title | Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer |
title_full | Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer |
title_fullStr | Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer |
title_full_unstemmed | Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer |
title_short | Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer |
title_sort | cost effective use of a thiosulfinate-enriched allium sativum extract in combination with chemotherapy in colon cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216288/ https://www.ncbi.nlm.nih.gov/pubmed/32316312 http://dx.doi.org/10.3390/ijms21082766 |
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