Bactericidal Activity of the Bacterial ATP Synthase Inhibitor Tomatidine and the Combination of Tomatidine and Aminoglycoside Against Persistent and Virulent Forms of Staphylococcus aureus

Tomatidine (TO), a steroid alkaloid, exerts a strong bactericidal activity on the infection-persistent phenotype of Staphylococcus aureus, the small-colony variant (SCV), with a minimal inhibitory concentration (MIC) of 0.06 μg/ml. Also, the combination of TO to an aminoglycoside (AMG) shows a stron...

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Detalles Bibliográficos
Autores principales: Langlois, Jean-Philippe, Millette, Guillaume, Guay, Isabelle, Dubé-Duquette, Alexis, Chamberland, Suzanne, Jacques, Pierre-Étienne, Rodrigue, Sébastien, Bouarab, Kamal, Marsault, Éric, Malouin, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216300/
https://www.ncbi.nlm.nih.gov/pubmed/32431678
http://dx.doi.org/10.3389/fmicb.2020.00805

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