The potential role of RNA N6-methyladenosine in Cancer progression

N6-methyladenosine (m6A) is considered the most common, abundant, and conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA). m6A is installed by m6A methyltransferases (METTL3/14, WTAP, RBM15/15B, VIRMA and ZC3H13, termed “writers”), removed by demethylases (FTO,...

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Autores principales: Wang, Tianyi, Kong, Shan, Tao, Mei, Ju, Shaoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216508/
https://www.ncbi.nlm.nih.gov/pubmed/32398132
http://dx.doi.org/10.1186/s12943-020-01204-7
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author Wang, Tianyi
Kong, Shan
Tao, Mei
Ju, Shaoqing
author_facet Wang, Tianyi
Kong, Shan
Tao, Mei
Ju, Shaoqing
author_sort Wang, Tianyi
collection PubMed
description N6-methyladenosine (m6A) is considered the most common, abundant, and conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA). m6A is installed by m6A methyltransferases (METTL3/14, WTAP, RBM15/15B, VIRMA and ZC3H13, termed “writers”), removed by demethylases (FTO, ALKBH5, and ALKBH3, termed “erasers”), and recognized by m6A-binding proteins (YTHDC1/2, YTHDF1/2/3, IGF2BP1/2/3, HNRNP, and eIF3, termed “readers”). Accumulating evidence suggests that m6A RNA methylation greatly impacts RNA metabolism and is involved in the pathogenesis of many kinds of diseases, including cancers. In this review, we focus on the physiological functions of m6A modification and its related regulators, as well as on the potential biological roles of these elements in human tumors.
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spelling pubmed-72165082020-05-18 The potential role of RNA N6-methyladenosine in Cancer progression Wang, Tianyi Kong, Shan Tao, Mei Ju, Shaoqing Mol Cancer Review N6-methyladenosine (m6A) is considered the most common, abundant, and conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA). m6A is installed by m6A methyltransferases (METTL3/14, WTAP, RBM15/15B, VIRMA and ZC3H13, termed “writers”), removed by demethylases (FTO, ALKBH5, and ALKBH3, termed “erasers”), and recognized by m6A-binding proteins (YTHDC1/2, YTHDF1/2/3, IGF2BP1/2/3, HNRNP, and eIF3, termed “readers”). Accumulating evidence suggests that m6A RNA methylation greatly impacts RNA metabolism and is involved in the pathogenesis of many kinds of diseases, including cancers. In this review, we focus on the physiological functions of m6A modification and its related regulators, as well as on the potential biological roles of these elements in human tumors. BioMed Central 2020-05-12 /pmc/articles/PMC7216508/ /pubmed/32398132 http://dx.doi.org/10.1186/s12943-020-01204-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wang, Tianyi
Kong, Shan
Tao, Mei
Ju, Shaoqing
The potential role of RNA N6-methyladenosine in Cancer progression
title The potential role of RNA N6-methyladenosine in Cancer progression
title_full The potential role of RNA N6-methyladenosine in Cancer progression
title_fullStr The potential role of RNA N6-methyladenosine in Cancer progression
title_full_unstemmed The potential role of RNA N6-methyladenosine in Cancer progression
title_short The potential role of RNA N6-methyladenosine in Cancer progression
title_sort potential role of rna n6-methyladenosine in cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216508/
https://www.ncbi.nlm.nih.gov/pubmed/32398132
http://dx.doi.org/10.1186/s12943-020-01204-7
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