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Gut microbiota in early pregnancy among women with Hyperglycaemia vs. Normal blood glucose
BACKGROUND: Recent studies suggest that there is a link between the gut microbiota and glucose metabolism. This study aimed to compare the gut microbiota during early pregnancy of women with hyperglycymia to those with normal blood glucose. METHODS: Gut microbial composition was analysed in 22 women...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216510/ https://www.ncbi.nlm.nih.gov/pubmed/32393255 http://dx.doi.org/10.1186/s12884-020-02961-5 |
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author | Gao, Beibei Zhong, Mengdan Shen, Qiong Wu, Ying Cao, Mengdie Ju, Songwen Chen, Lei |
author_facet | Gao, Beibei Zhong, Mengdan Shen, Qiong Wu, Ying Cao, Mengdie Ju, Songwen Chen, Lei |
author_sort | Gao, Beibei |
collection | PubMed |
description | BACKGROUND: Recent studies suggest that there is a link between the gut microbiota and glucose metabolism. This study aimed to compare the gut microbiota during early pregnancy of women with hyperglycymia to those with normal blood glucose. METHODS: Gut microbial composition was analysed in 22 women with hyperglycaemia and 28 age-matched healthy controls during their first prenatal visits (< 20 weeks) using high throughput sequencing of the V3-V4 region of the 16S ribosomal RNA gene. Hyperglycemia was diagnosed based on the criteria recommended by the International Association of Diabetes and Pregnancy Study Groups in 2010. RESULTS: Women with hyperglycemia in pregnancy (HIP) had significantly lower microbial richness and diversity compared with healthy pregnant women. The proportions of the Firmicutes and Bacteroidetes phyla and the ratio of Firmicutes:Bacteroidetes were not different between the two groups. We observed that individuals with HIP had an increased abundance of Nocardiaceae, Fusobacteriaceae, etc., whereas healthy controls had significantly higher levels of Christensenellaceae, Clostridiales_vadinBB60_group, Coriobacteriaceae, etc. Similarly, levels of the members of the Ruminococcaceae family, including Ruminococcaceae_UCG-014, Ruminococcaceae_UCG-003, and Ruminococcaceae_UCG-002, were significantly reduced in the HIP group and were negatively correlated with HbA1c. HbA1c levels were positively correlated with Bacteroidaceae and Enterobacteriaceae and negatively correlated with Christensenellaceae, etc. CRP was positively correlated with the Bacteroidaceae and Fusobacteriaceae families and the Fusobacterium genus. CONCLUSIONS: Our study revealed that individuals with HIP have gut microbial dysbiosis and that certain bacterial groups are associated with glucose metabolism during pregnancy. Further study is needed to provide new ideas to control glucose by modifying the gut microbiota. |
format | Online Article Text |
id | pubmed-7216510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-72165102020-05-18 Gut microbiota in early pregnancy among women with Hyperglycaemia vs. Normal blood glucose Gao, Beibei Zhong, Mengdan Shen, Qiong Wu, Ying Cao, Mengdie Ju, Songwen Chen, Lei BMC Pregnancy Childbirth Research Article BACKGROUND: Recent studies suggest that there is a link between the gut microbiota and glucose metabolism. This study aimed to compare the gut microbiota during early pregnancy of women with hyperglycymia to those with normal blood glucose. METHODS: Gut microbial composition was analysed in 22 women with hyperglycaemia and 28 age-matched healthy controls during their first prenatal visits (< 20 weeks) using high throughput sequencing of the V3-V4 region of the 16S ribosomal RNA gene. Hyperglycemia was diagnosed based on the criteria recommended by the International Association of Diabetes and Pregnancy Study Groups in 2010. RESULTS: Women with hyperglycemia in pregnancy (HIP) had significantly lower microbial richness and diversity compared with healthy pregnant women. The proportions of the Firmicutes and Bacteroidetes phyla and the ratio of Firmicutes:Bacteroidetes were not different between the two groups. We observed that individuals with HIP had an increased abundance of Nocardiaceae, Fusobacteriaceae, etc., whereas healthy controls had significantly higher levels of Christensenellaceae, Clostridiales_vadinBB60_group, Coriobacteriaceae, etc. Similarly, levels of the members of the Ruminococcaceae family, including Ruminococcaceae_UCG-014, Ruminococcaceae_UCG-003, and Ruminococcaceae_UCG-002, were significantly reduced in the HIP group and were negatively correlated with HbA1c. HbA1c levels were positively correlated with Bacteroidaceae and Enterobacteriaceae and negatively correlated with Christensenellaceae, etc. CRP was positively correlated with the Bacteroidaceae and Fusobacteriaceae families and the Fusobacterium genus. CONCLUSIONS: Our study revealed that individuals with HIP have gut microbial dysbiosis and that certain bacterial groups are associated with glucose metabolism during pregnancy. Further study is needed to provide new ideas to control glucose by modifying the gut microbiota. BioMed Central 2020-05-11 /pmc/articles/PMC7216510/ /pubmed/32393255 http://dx.doi.org/10.1186/s12884-020-02961-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Gao, Beibei Zhong, Mengdan Shen, Qiong Wu, Ying Cao, Mengdie Ju, Songwen Chen, Lei Gut microbiota in early pregnancy among women with Hyperglycaemia vs. Normal blood glucose |
title | Gut microbiota in early pregnancy among women with Hyperglycaemia vs. Normal blood glucose |
title_full | Gut microbiota in early pregnancy among women with Hyperglycaemia vs. Normal blood glucose |
title_fullStr | Gut microbiota in early pregnancy among women with Hyperglycaemia vs. Normal blood glucose |
title_full_unstemmed | Gut microbiota in early pregnancy among women with Hyperglycaemia vs. Normal blood glucose |
title_short | Gut microbiota in early pregnancy among women with Hyperglycaemia vs. Normal blood glucose |
title_sort | gut microbiota in early pregnancy among women with hyperglycaemia vs. normal blood glucose |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216510/ https://www.ncbi.nlm.nih.gov/pubmed/32393255 http://dx.doi.org/10.1186/s12884-020-02961-5 |
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