Differential responsiveness to BRAF inhibitors of melanoma cell lines BRAF V600E-mutated

BACKGROUND: Most mutations in melanoma affect one critical amino acid on BRAF gene, resulting in the V600E substitution. Patient management is often based on the use of specific inhibitors targeting this mutation. METHODS: DNA and RNA mutation status was assessed in 15 melanoma cell lines by Sanger...

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Detalles Bibliográficos
Autores principales: Al Hashmi, Muna, Sastry, Konduru S., Silcock, Lee, Chouchane, Lotfi, Mattei, Valentina, James, Nicola, Mathew, Rebecca, Bedognetti, Davide, De Giorgi, Valeria, Murtas, Daniela, Liu, Wei, Chouchane, Aouatef, Temanni, Ramzi, Seliger, Barbara, Wang, Ena, Marincola, Francesco M., Tomei, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216681/
https://www.ncbi.nlm.nih.gov/pubmed/32393282
http://dx.doi.org/10.1186/s12967-020-02350-8

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