DNA methylation disruption reshapes the hematopoietic differentiation landscape

Mutations in genes involved in DNA methylation (DNAme; e.g., TET2, DNMT3A), are frequently observed in hematological malignancies(1–3) and clonal hematopoiesis(4,5). Applying single-cell sequencing to murine hematopoietic stem and progenitor cells, we observed that these mutations disrupt hematopoie...

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Detalles Bibliográficos
Autores principales: Izzo, Franco, Lee, Stanley C., Poran, Asaf, Chaligne, Ronan, Gaiti, Federico, Gross, Baptiste, Murali, Rekha R., Deochand, Sunil D., Ang, Chelston, Jones, Philippa Wyndham, Nam, Anna S., Kim, Kyu-Tae, Kothen-Hill, Steven, Schulman, Rafael C., Ki, Michelle, Lhoumaud, Priscillia, Skok, Jane A., Viny, Aaron D., Levine, Ross L., Kenigsberg, Ephraim, Abdel-Wahab, Omar, Landau, Dan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216752/
https://www.ncbi.nlm.nih.gov/pubmed/32203468
http://dx.doi.org/10.1038/s41588-020-0595-4

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