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Estimated effectiveness of traveller screening to prevent international spread of 2019 novel coronavirus (2019-nCoV)

Traveller screening is being used to limit further global spread of 2019 novel coronavirus (nCoV) following its recent emergence. Here, we project the impact of different travel screening programs given remaining uncertainty around the values of key nCoV life history and epidemiological parameters....

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Autores principales: Gostic, Katelyn M., Gomez, Ana C. R., Mummah, Riley O., Kucharski, Adam J., Lloyd-Smith, James O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216848/
https://www.ncbi.nlm.nih.gov/pubmed/32511422
http://dx.doi.org/10.1101/2020.01.28.20019224
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author Gostic, Katelyn M.
Gomez, Ana C. R.
Mummah, Riley O.
Kucharski, Adam J.
Lloyd-Smith, James O.
author_facet Gostic, Katelyn M.
Gomez, Ana C. R.
Mummah, Riley O.
Kucharski, Adam J.
Lloyd-Smith, James O.
author_sort Gostic, Katelyn M.
collection PubMed
description Traveller screening is being used to limit further global spread of 2019 novel coronavirus (nCoV) following its recent emergence. Here, we project the impact of different travel screening programs given remaining uncertainty around the values of key nCoV life history and epidemiological parameters. Even under best-case assumptions, we estimate that screening will miss more than half of infected travellers. Breaking down the factors leading to screening successes and failures, we find that most cases missed by screening are fundamentally undetectable, because they have not yet developed symptoms and are unaware they were exposed. These findings emphasize the need for measures to track travellers who become ill after being missed by a travel screening program. We make our model available for interactive use so stakeholders can explore scenarios of interest using the most up-to-date information. We hope these findings contribute to evidence-based policy to combat the spread of nCoV, and to prospective planning to mitigate future emerging pathogens.
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spelling pubmed-72168482020-06-07 Estimated effectiveness of traveller screening to prevent international spread of 2019 novel coronavirus (2019-nCoV) Gostic, Katelyn M. Gomez, Ana C. R. Mummah, Riley O. Kucharski, Adam J. Lloyd-Smith, James O. medRxiv Article Traveller screening is being used to limit further global spread of 2019 novel coronavirus (nCoV) following its recent emergence. Here, we project the impact of different travel screening programs given remaining uncertainty around the values of key nCoV life history and epidemiological parameters. Even under best-case assumptions, we estimate that screening will miss more than half of infected travellers. Breaking down the factors leading to screening successes and failures, we find that most cases missed by screening are fundamentally undetectable, because they have not yet developed symptoms and are unaware they were exposed. These findings emphasize the need for measures to track travellers who become ill after being missed by a travel screening program. We make our model available for interactive use so stakeholders can explore scenarios of interest using the most up-to-date information. We hope these findings contribute to evidence-based policy to combat the spread of nCoV, and to prospective planning to mitigate future emerging pathogens. Cold Spring Harbor Laboratory 2020-02-03 /pmc/articles/PMC7216848/ /pubmed/32511422 http://dx.doi.org/10.1101/2020.01.28.20019224 Text en http://creativecommons.org/licenses/by-nc/4.0/It is made available under a CC-BY-NC 4.0 International license (http://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Article
Gostic, Katelyn M.
Gomez, Ana C. R.
Mummah, Riley O.
Kucharski, Adam J.
Lloyd-Smith, James O.
Estimated effectiveness of traveller screening to prevent international spread of 2019 novel coronavirus (2019-nCoV)
title Estimated effectiveness of traveller screening to prevent international spread of 2019 novel coronavirus (2019-nCoV)
title_full Estimated effectiveness of traveller screening to prevent international spread of 2019 novel coronavirus (2019-nCoV)
title_fullStr Estimated effectiveness of traveller screening to prevent international spread of 2019 novel coronavirus (2019-nCoV)
title_full_unstemmed Estimated effectiveness of traveller screening to prevent international spread of 2019 novel coronavirus (2019-nCoV)
title_short Estimated effectiveness of traveller screening to prevent international spread of 2019 novel coronavirus (2019-nCoV)
title_sort estimated effectiveness of traveller screening to prevent international spread of 2019 novel coronavirus (2019-ncov)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216848/
https://www.ncbi.nlm.nih.gov/pubmed/32511422
http://dx.doi.org/10.1101/2020.01.28.20019224
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