Focal and generalized seizure activity after local hippocampal or cortical ablation of Na(V)1.1 channels in mice

Early onset seizures are a hallmark of Dravet syndrome. Previous studies in rodent models have shown that the epileptic phenotype is caused by loss‐of‐function of voltage‐gated Na(V)1.1 sodium channels, which are chiefly expressed in γ‐aminobutyric acid (GABA)ergic neurons. Recently, a possibly crit...

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Detalles Bibliográficos
Autores principales: Jansen, Nico A., Dehghani, Anisa, Breukel, Cor, Tolner, Else A., van den Maagdenberg, Arn M. J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216883/
https://www.ncbi.nlm.nih.gov/pubmed/32190912
http://dx.doi.org/10.1111/epi.16482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216883/
https://www.ncbi.nlm.nih.gov/pubmed/32190912
http://dx.doi.org/10.1111/epi.16482

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