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Novel interpenetrating polymer network provides significant and long‐lasting improvements in hydration to the skin from different body areas

BACKGROUND: Hydration and moisturization both impact skin quality, directly reflecting its appearance. Signs and onset of dehydration‐related skin aging are region‐specific and require tailored treatment to be effective. AIMS: To test the hydrating effects of formulas containing a novel 3‐dimensiona...

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Autores principales: Falla, Timothy, Rodan, Katie, Fields, Kathy, Bianchini, Robert, Mahon, Cullin, Skobowiat, Cezary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216996/
https://www.ncbi.nlm.nih.gov/pubmed/31498539
http://dx.doi.org/10.1111/jocd.13136
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author Falla, Timothy
Rodan, Katie
Fields, Kathy
Bianchini, Robert
Mahon, Cullin
Skobowiat, Cezary
author_facet Falla, Timothy
Rodan, Katie
Fields, Kathy
Bianchini, Robert
Mahon, Cullin
Skobowiat, Cezary
author_sort Falla, Timothy
collection PubMed
description BACKGROUND: Hydration and moisturization both impact skin quality, directly reflecting its appearance. Signs and onset of dehydration‐related skin aging are region‐specific and require tailored treatment to be effective. AIMS: To test the hydrating effects of formulas containing a novel 3‐dimensional 3‐polymer interpenetrating network (3D3P‐IPN) to deliver humectants and actives to specific body sites. METHODS: Two clinical studies were conducted focused on the skin under eyes and body (arms/legs). Healthy women ages 25‐65 (eyes) or 35‐65 (body) with mild to moderate dry and aged skin were enrolled. Study product containing the 3D3P‐IPN and tailored actives was applied twice daily for 8 weeks on the periorbital area and for 4 weeks on the body. Changes in skin attributes were measured by biophysical instrumentation for hydration, dark circles, skin color, elasticity and transepidermal water loss, and by clinical grading and subject self‐assessment. RESULTS: Significant improvements in hydration and skin smoothing were demonstrated in both studies. In the periorbital region, actives and humectants delivered by the 3D3P‐IPN also led to significant improvements in dark circles, fine lines/crow's feet, puffiness, restoring radiance, and overall younger‐looking appearance. On the arms and legs, there were significant reductions in crepiness and dullness. The arms and legs also had improvements in tactile and visual skin texture, radiance, and general healthy look. Improvements were immediate and persisted through the end of both studies. CONCLUSION: The 3D3P‐IPN provides immediate and long‐lasting improvements in skin hydration and overall healthy appearance regardless of the targeted application site.
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spelling pubmed-72169962020-05-13 Novel interpenetrating polymer network provides significant and long‐lasting improvements in hydration to the skin from different body areas Falla, Timothy Rodan, Katie Fields, Kathy Bianchini, Robert Mahon, Cullin Skobowiat, Cezary J Cosmet Dermatol Basic Science Cosmectic Dermatology Articles BACKGROUND: Hydration and moisturization both impact skin quality, directly reflecting its appearance. Signs and onset of dehydration‐related skin aging are region‐specific and require tailored treatment to be effective. AIMS: To test the hydrating effects of formulas containing a novel 3‐dimensional 3‐polymer interpenetrating network (3D3P‐IPN) to deliver humectants and actives to specific body sites. METHODS: Two clinical studies were conducted focused on the skin under eyes and body (arms/legs). Healthy women ages 25‐65 (eyes) or 35‐65 (body) with mild to moderate dry and aged skin were enrolled. Study product containing the 3D3P‐IPN and tailored actives was applied twice daily for 8 weeks on the periorbital area and for 4 weeks on the body. Changes in skin attributes were measured by biophysical instrumentation for hydration, dark circles, skin color, elasticity and transepidermal water loss, and by clinical grading and subject self‐assessment. RESULTS: Significant improvements in hydration and skin smoothing were demonstrated in both studies. In the periorbital region, actives and humectants delivered by the 3D3P‐IPN also led to significant improvements in dark circles, fine lines/crow's feet, puffiness, restoring radiance, and overall younger‐looking appearance. On the arms and legs, there were significant reductions in crepiness and dullness. The arms and legs also had improvements in tactile and visual skin texture, radiance, and general healthy look. Improvements were immediate and persisted through the end of both studies. CONCLUSION: The 3D3P‐IPN provides immediate and long‐lasting improvements in skin hydration and overall healthy appearance regardless of the targeted application site. John Wiley and Sons Inc. 2019-09-09 2020-05 /pmc/articles/PMC7216996/ /pubmed/31498539 http://dx.doi.org/10.1111/jocd.13136 Text en © 2019 Rodan+Fields. Journal of Cosmetic Dermatology published by Wiley Periodicals, Inc This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Basic Science Cosmectic Dermatology Articles
Falla, Timothy
Rodan, Katie
Fields, Kathy
Bianchini, Robert
Mahon, Cullin
Skobowiat, Cezary
Novel interpenetrating polymer network provides significant and long‐lasting improvements in hydration to the skin from different body areas
title Novel interpenetrating polymer network provides significant and long‐lasting improvements in hydration to the skin from different body areas
title_full Novel interpenetrating polymer network provides significant and long‐lasting improvements in hydration to the skin from different body areas
title_fullStr Novel interpenetrating polymer network provides significant and long‐lasting improvements in hydration to the skin from different body areas
title_full_unstemmed Novel interpenetrating polymer network provides significant and long‐lasting improvements in hydration to the skin from different body areas
title_short Novel interpenetrating polymer network provides significant and long‐lasting improvements in hydration to the skin from different body areas
title_sort novel interpenetrating polymer network provides significant and long‐lasting improvements in hydration to the skin from different body areas
topic Basic Science Cosmectic Dermatology Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216996/
https://www.ncbi.nlm.nih.gov/pubmed/31498539
http://dx.doi.org/10.1111/jocd.13136
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