Metals in Biotechnology: Cr‐Driven Stereoselective Reduction of Conjugated C=C Double Bonds

Elemental metals are shown to be suitable sacrificial electron donors to drive the stereoselective reduction of conjugated C=C double bonds using Old Yellow Enzymes as catalysts. Both direct electron transfer from the metal to the enzyme as well as mediated electron transfer is feasible, although th...

Descripción completa

Detalles Bibliográficos
Autores principales: Rauch, Marine C. R., Gallou, Yann, Delorme, Léna, Paul, Caroline E., Arends, Isabel W. C. E., Hollmann, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217005/
https://www.ncbi.nlm.nih.gov/pubmed/31713969
http://dx.doi.org/10.1002/cbic.201900685
_version_ 1783532528587505664
author Rauch, Marine C. R.
Gallou, Yann
Delorme, Léna
Paul, Caroline E.
Arends, Isabel W. C. E.
Hollmann, Frank
author_facet Rauch, Marine C. R.
Gallou, Yann
Delorme, Léna
Paul, Caroline E.
Arends, Isabel W. C. E.
Hollmann, Frank
author_sort Rauch, Marine C. R.
collection PubMed
description Elemental metals are shown to be suitable sacrificial electron donors to drive the stereoselective reduction of conjugated C=C double bonds using Old Yellow Enzymes as catalysts. Both direct electron transfer from the metal to the enzyme as well as mediated electron transfer is feasible, although the latter excels by higher reaction rates. The general applicability of this new chemoenzymatic reduction method is demonstrated, and current limitations are outlined.
format Online
Article
Text
id pubmed-7217005
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-72170052020-05-13 Metals in Biotechnology: Cr‐Driven Stereoselective Reduction of Conjugated C=C Double Bonds Rauch, Marine C. R. Gallou, Yann Delorme, Léna Paul, Caroline E. Arends, Isabel W. C. E. Hollmann, Frank Chembiochem Communications Elemental metals are shown to be suitable sacrificial electron donors to drive the stereoselective reduction of conjugated C=C double bonds using Old Yellow Enzymes as catalysts. Both direct electron transfer from the metal to the enzyme as well as mediated electron transfer is feasible, although the latter excels by higher reaction rates. The general applicability of this new chemoenzymatic reduction method is demonstrated, and current limitations are outlined. John Wiley and Sons Inc. 2019-12-19 2020-04-17 /pmc/articles/PMC7217005/ /pubmed/31713969 http://dx.doi.org/10.1002/cbic.201900685 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Rauch, Marine C. R.
Gallou, Yann
Delorme, Léna
Paul, Caroline E.
Arends, Isabel W. C. E.
Hollmann, Frank
Metals in Biotechnology: Cr‐Driven Stereoselective Reduction of Conjugated C=C Double Bonds
title Metals in Biotechnology: Cr‐Driven Stereoselective Reduction of Conjugated C=C Double Bonds
title_full Metals in Biotechnology: Cr‐Driven Stereoselective Reduction of Conjugated C=C Double Bonds
title_fullStr Metals in Biotechnology: Cr‐Driven Stereoselective Reduction of Conjugated C=C Double Bonds
title_full_unstemmed Metals in Biotechnology: Cr‐Driven Stereoselective Reduction of Conjugated C=C Double Bonds
title_short Metals in Biotechnology: Cr‐Driven Stereoselective Reduction of Conjugated C=C Double Bonds
title_sort metals in biotechnology: cr‐driven stereoselective reduction of conjugated c=c double bonds
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217005/
https://www.ncbi.nlm.nih.gov/pubmed/31713969
http://dx.doi.org/10.1002/cbic.201900685
work_keys_str_mv AT rauchmarinecr metalsinbiotechnologycrdrivenstereoselectivereductionofconjugatedccdoublebonds
AT gallouyann metalsinbiotechnologycrdrivenstereoselectivereductionofconjugatedccdoublebonds
AT delormelena metalsinbiotechnologycrdrivenstereoselectivereductionofconjugatedccdoublebonds
AT paulcarolinee metalsinbiotechnologycrdrivenstereoselectivereductionofconjugatedccdoublebonds
AT arendsisabelwce metalsinbiotechnologycrdrivenstereoselectivereductionofconjugatedccdoublebonds
AT hollmannfrank metalsinbiotechnologycrdrivenstereoselectivereductionofconjugatedccdoublebonds

Ejemplares similares