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Metals in Biotechnology: Cr‐Driven Stereoselective Reduction of Conjugated C=C Double Bonds
Elemental metals are shown to be suitable sacrificial electron donors to drive the stereoselective reduction of conjugated C=C double bonds using Old Yellow Enzymes as catalysts. Both direct electron transfer from the metal to the enzyme as well as mediated electron transfer is feasible, although th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217005/ https://www.ncbi.nlm.nih.gov/pubmed/31713969 http://dx.doi.org/10.1002/cbic.201900685 |
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author | Rauch, Marine C. R. Gallou, Yann Delorme, Léna Paul, Caroline E. Arends, Isabel W. C. E. Hollmann, Frank |
author_facet | Rauch, Marine C. R. Gallou, Yann Delorme, Léna Paul, Caroline E. Arends, Isabel W. C. E. Hollmann, Frank |
author_sort | Rauch, Marine C. R. |
collection | PubMed |
description | Elemental metals are shown to be suitable sacrificial electron donors to drive the stereoselective reduction of conjugated C=C double bonds using Old Yellow Enzymes as catalysts. Both direct electron transfer from the metal to the enzyme as well as mediated electron transfer is feasible, although the latter excels by higher reaction rates. The general applicability of this new chemoenzymatic reduction method is demonstrated, and current limitations are outlined. |
format | Online Article Text |
id | pubmed-7217005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72170052020-05-13 Metals in Biotechnology: Cr‐Driven Stereoselective Reduction of Conjugated C=C Double Bonds Rauch, Marine C. R. Gallou, Yann Delorme, Léna Paul, Caroline E. Arends, Isabel W. C. E. Hollmann, Frank Chembiochem Communications Elemental metals are shown to be suitable sacrificial electron donors to drive the stereoselective reduction of conjugated C=C double bonds using Old Yellow Enzymes as catalysts. Both direct electron transfer from the metal to the enzyme as well as mediated electron transfer is feasible, although the latter excels by higher reaction rates. The general applicability of this new chemoenzymatic reduction method is demonstrated, and current limitations are outlined. John Wiley and Sons Inc. 2019-12-19 2020-04-17 /pmc/articles/PMC7217005/ /pubmed/31713969 http://dx.doi.org/10.1002/cbic.201900685 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Communications Rauch, Marine C. R. Gallou, Yann Delorme, Léna Paul, Caroline E. Arends, Isabel W. C. E. Hollmann, Frank Metals in Biotechnology: Cr‐Driven Stereoselective Reduction of Conjugated C=C Double Bonds |
title | Metals in Biotechnology: Cr‐Driven Stereoselective Reduction of Conjugated C=C Double Bonds |
title_full | Metals in Biotechnology: Cr‐Driven Stereoselective Reduction of Conjugated C=C Double Bonds |
title_fullStr | Metals in Biotechnology: Cr‐Driven Stereoselective Reduction of Conjugated C=C Double Bonds |
title_full_unstemmed | Metals in Biotechnology: Cr‐Driven Stereoselective Reduction of Conjugated C=C Double Bonds |
title_short | Metals in Biotechnology: Cr‐Driven Stereoselective Reduction of Conjugated C=C Double Bonds |
title_sort | metals in biotechnology: cr‐driven stereoselective reduction of conjugated c=c double bonds |
topic | Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217005/ https://www.ncbi.nlm.nih.gov/pubmed/31713969 http://dx.doi.org/10.1002/cbic.201900685 |
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