Validation of the Slow Off‐Kinetics of Sirtuin‐Rearranging Ligands (SirReals) by Means of Label‐Free Electrically Switchable Nanolever Technology

We have discovered the sirtuin‐rearranging ligands (SirReals) to be highly potent and selective inhibitors of the NAD(+)‐dependent lysine deacetylase Sirt2. Using a biotinylated SirReal in combination with biolayer interferometry, we previously observed a slow dissociation rate of the inhibitor–enzy...

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Detalles Bibliográficos
Autores principales: Schiedel, Matthias, Daub, Herwin, Itzen, Aymelt, Jung, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217041/
https://www.ncbi.nlm.nih.gov/pubmed/31692222
http://dx.doi.org/10.1002/cbic.201900527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217041/
https://www.ncbi.nlm.nih.gov/pubmed/31692222
http://dx.doi.org/10.1002/cbic.201900527

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