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Obesity as a predictor for a poor prognosis of COVID-19: A systematic review

BACKGROUND AND AIMS: COVID-19 is an emerging pandemic due to droplet infection of 2019-novel coronavirus (2019-nCoV). Due to its rapid transmission and high case-fatality rate, recognition of its risk and prognostic factor is important. Obesity has been associated with impaired immune system, increa...

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Autores principales: Tamara, Alice, Tahapary, Dicky L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Diabetes India. Published by Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217103/
https://www.ncbi.nlm.nih.gov/pubmed/32438328
http://dx.doi.org/10.1016/j.dsx.2020.05.020
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author Tamara, Alice
Tahapary, Dicky L.
author_facet Tamara, Alice
Tahapary, Dicky L.
author_sort Tamara, Alice
collection PubMed
description BACKGROUND AND AIMS: COVID-19 is an emerging pandemic due to droplet infection of 2019-novel coronavirus (2019-nCoV). Due to its rapid transmission and high case-fatality rate, recognition of its risk and prognostic factor is important. Obesity has been associated with impaired immune system, increasing the susceptibility for 2019-nCoV infection. We aimed to study the impact of obesity to the prognosis and disease severity of COVID-19. METHODS: A systematic search and handsearching was conducted in four databases: Cochrane, MEDLINE, EMBASE, and PubMed. The identified articles were screened using the chosen eligibility criteria. We obtained three retrospective cohort studies (Wu J et al., Lighter J et al., and Simonnet A et al.) to be critically appraised using Newcastle Ottawa Scale. RESULTS: The findings of all included studies were consistent in stating the contribution of obesity as a risk factor to increase the requirement for advanced medical care. Study with the highest quality, Simonnet A et al., reported an increase need of invasive mechanical ventilation in COVID-19 patients with body mass index higher than 35 kg/m(2), OR: 7.36 (1.63–33.14; p = 0.021). This is associated with a higher mortality rate in obese population infected with COVID-19. CONCLUSION: Obesity is an independent risk and prognostic factor for the disease severity and the requirement of advanced medical care in COVID-19. This systematic review highlights a particularly vulnerable group – obese, and emphasises on the importance of treatment aggression and disease prevention in this population group.
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spelling pubmed-72171032020-05-12 Obesity as a predictor for a poor prognosis of COVID-19: A systematic review Tamara, Alice Tahapary, Dicky L. Diabetes Metab Syndr Article BACKGROUND AND AIMS: COVID-19 is an emerging pandemic due to droplet infection of 2019-novel coronavirus (2019-nCoV). Due to its rapid transmission and high case-fatality rate, recognition of its risk and prognostic factor is important. Obesity has been associated with impaired immune system, increasing the susceptibility for 2019-nCoV infection. We aimed to study the impact of obesity to the prognosis and disease severity of COVID-19. METHODS: A systematic search and handsearching was conducted in four databases: Cochrane, MEDLINE, EMBASE, and PubMed. The identified articles were screened using the chosen eligibility criteria. We obtained three retrospective cohort studies (Wu J et al., Lighter J et al., and Simonnet A et al.) to be critically appraised using Newcastle Ottawa Scale. RESULTS: The findings of all included studies were consistent in stating the contribution of obesity as a risk factor to increase the requirement for advanced medical care. Study with the highest quality, Simonnet A et al., reported an increase need of invasive mechanical ventilation in COVID-19 patients with body mass index higher than 35 kg/m(2), OR: 7.36 (1.63–33.14; p = 0.021). This is associated with a higher mortality rate in obese population infected with COVID-19. CONCLUSION: Obesity is an independent risk and prognostic factor for the disease severity and the requirement of advanced medical care in COVID-19. This systematic review highlights a particularly vulnerable group – obese, and emphasises on the importance of treatment aggression and disease prevention in this population group. Diabetes India. Published by Elsevier Ltd. 2020 2020-05-12 /pmc/articles/PMC7217103/ /pubmed/32438328 http://dx.doi.org/10.1016/j.dsx.2020.05.020 Text en © 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Tamara, Alice
Tahapary, Dicky L.
Obesity as a predictor for a poor prognosis of COVID-19: A systematic review
title Obesity as a predictor for a poor prognosis of COVID-19: A systematic review
title_full Obesity as a predictor for a poor prognosis of COVID-19: A systematic review
title_fullStr Obesity as a predictor for a poor prognosis of COVID-19: A systematic review
title_full_unstemmed Obesity as a predictor for a poor prognosis of COVID-19: A systematic review
title_short Obesity as a predictor for a poor prognosis of COVID-19: A systematic review
title_sort obesity as a predictor for a poor prognosis of covid-19: a systematic review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217103/
https://www.ncbi.nlm.nih.gov/pubmed/32438328
http://dx.doi.org/10.1016/j.dsx.2020.05.020
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