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COVID-19: beta-thalassemia subjects immunised?

The novel coronavirus pneumonia (COVID-19) is a contagious acute respiratory infectious disease whose causative agent has been demonstrated to be a novel virus of the coronavirus family, SARSCoV-2. A recent PRE-print study has showed a heme attack on the 1-beta chain of hemoglobin by COVID19. Beta-t...

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Autores principales: Lansiaux, Edouard, Pébaÿ, Philippe Pierre, Picard, Jean-Laurent, Son-Forget, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217120/
https://www.ncbi.nlm.nih.gov/pubmed/32447232
http://dx.doi.org/10.1016/j.mehy.2020.109827
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author Lansiaux, Edouard
Pébaÿ, Philippe Pierre
Picard, Jean-Laurent
Son-Forget, Joachim
author_facet Lansiaux, Edouard
Pébaÿ, Philippe Pierre
Picard, Jean-Laurent
Son-Forget, Joachim
author_sort Lansiaux, Edouard
collection PubMed
description The novel coronavirus pneumonia (COVID-19) is a contagious acute respiratory infectious disease whose causative agent has been demonstrated to be a novel virus of the coronavirus family, SARSCoV-2. A recent PRE-print study has showed a heme attack on the 1-beta chain of hemoglobin by COVID19. Beta-thalassemia results of a default in the hemoglobin beta-chain synthesis. 1,5% global population are heterozygotes for this disease. In this study, by a multiple linear regression, we have analyzed the evolution of COVID-19 infection in three Italian regions (Puglia, Sardinia, Sicilia) with different beta-thalassemic prevalences, in order to search a link. The results have showed that betathalassemic heterozygote population prevalence is correlated to immunity against COVID-19, by a regression. This paper is only for academic discussion, the hypotheses and conclusions needs to be confirmed by further research.
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spelling pubmed-72171202020-05-12 COVID-19: beta-thalassemia subjects immunised? Lansiaux, Edouard Pébaÿ, Philippe Pierre Picard, Jean-Laurent Son-Forget, Joachim Med Hypotheses Article The novel coronavirus pneumonia (COVID-19) is a contagious acute respiratory infectious disease whose causative agent has been demonstrated to be a novel virus of the coronavirus family, SARSCoV-2. A recent PRE-print study has showed a heme attack on the 1-beta chain of hemoglobin by COVID19. Beta-thalassemia results of a default in the hemoglobin beta-chain synthesis. 1,5% global population are heterozygotes for this disease. In this study, by a multiple linear regression, we have analyzed the evolution of COVID-19 infection in three Italian regions (Puglia, Sardinia, Sicilia) with different beta-thalassemic prevalences, in order to search a link. The results have showed that betathalassemic heterozygote population prevalence is correlated to immunity against COVID-19, by a regression. This paper is only for academic discussion, the hypotheses and conclusions needs to be confirmed by further research. Elsevier Ltd. 2020-09 2020-05-12 /pmc/articles/PMC7217120/ /pubmed/32447232 http://dx.doi.org/10.1016/j.mehy.2020.109827 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Lansiaux, Edouard
Pébaÿ, Philippe Pierre
Picard, Jean-Laurent
Son-Forget, Joachim
COVID-19: beta-thalassemia subjects immunised?
title COVID-19: beta-thalassemia subjects immunised?
title_full COVID-19: beta-thalassemia subjects immunised?
title_fullStr COVID-19: beta-thalassemia subjects immunised?
title_full_unstemmed COVID-19: beta-thalassemia subjects immunised?
title_short COVID-19: beta-thalassemia subjects immunised?
title_sort covid-19: beta-thalassemia subjects immunised?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217120/
https://www.ncbi.nlm.nih.gov/pubmed/32447232
http://dx.doi.org/10.1016/j.mehy.2020.109827
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